Ventral Mesencephalon-Enriched Genes That Regulate the Development of Dopaminergic Neurons In Vivo

	Ventral Mesencephalon-Enriched Genes That Regulate the Development of Dopaminergic Neurons In Vivo
	Yin, M; Liu, SX; Yin, YQ; Li, S; Li, ZH; Wu, XF; Zhang, B; Ang, SL; Ding, YQ; Zhou, JW
刊名	JOURNAL OF NEUROSCIENCE
	2009
卷号	29 期号:16 页码:5170-5182
通讯作者	Zhou, JW (reprint author), Chinese Acad Sci, Inst Neurosci, 320 Yueyang Rd, Shanghai 200031, Peoples R China.,jwzhou@ion.ac.cn
英文摘要	Mesodiencephalic dopaminergic (mDA) neurons are critical for movement control and other physiological activities. However, the molecular mechanisms underlying their development are poorly understood. We aimed to establish the expression profiles of genes involved in this process and unravel genetic programs that control late development of mDA neurons. We compared genome-wide gene expression profiles of developing mouse ventral mesencephalon (VM) using microarrays. We identified a set of genes that show spatially and temporally restricted expression in the VM in an Ngn2 ( neurogenin 2)-dependent manner and are potentially important for mDA neuron development. Functional analysis on mice lacking the VM-specific gene early B-cell factor 1 (Ebf1) revealed that Ebf1 is essential for the terminal migration of mDA neurons in the substantia nigra pars compacta. Thus, we identified a set of VM-enriched genes that are important for mDA neuron development. Our analysis also provides a genetic framework for further investigation of the molecular mechanisms mediating mDA neuron development.
学科主题	Neurosciences & Neurology
类目[WOS]	Neurosciences
关键词[WOS]	RADIAL GLIA ; CELLS ; RAT ; DIFFERENTIATION ; SPECIFICATION ; NEUROGENIN-2 ; EXPRESSION ; PROJECTION ; MIGRATION ; STRIATUM
收录类别	SCI
语种	英语
WOS记录号	WOS:000265450300015
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1279]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Yin, M,Liu, SX,Yin, YQ,et al. Ventral Mesencephalon-Enriched Genes That Regulate the Development of Dopaminergic Neurons In Vivo[J]. JOURNAL OF NEUROSCIENCE,2009,29(16):5170-5182.
APA	Yin, M.,Liu, SX.,Yin, YQ.,Li, S.,Li, ZH.,...&Zhou, JW.(2009).Ventral Mesencephalon-Enriched Genes That Regulate the Development of Dopaminergic Neurons In Vivo.JOURNAL OF NEUROSCIENCE,29(16),5170-5182.
MLA	Yin, M,et al."Ventral Mesencephalon-Enriched Genes That Regulate the Development of Dopaminergic Neurons In Vivo".JOURNAL OF NEUROSCIENCE 29.16(2009):5170-5182.