Znhit1 causes cell cycle arrest and down-regulates CDK6 expression

	Znhit1 causes cell cycle arrest and down-regulates CDK6 expression
	Yang, ZM; Cao, YH; Zhu, XY; Huang, Y; Ding, YQ; Liu, XL
刊名	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
	2009
卷号	386 期号:1 页码:146-152
关键词	Zf-HIT domain Znhit1 Cell cycle arrest CDK6 T cell proliferation
通讯作者	Liu, XL (reprint author), Chinese Acad Sci, Mol Cell Biol Lab, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China.,liux@sibs.ac.cn
英文摘要	Cyclin-dependent kinase 6 (CDK6) is the key element of the D-type cyclin holoenzymes which has been found to function in the regulation of G1-phase of the cell cycle and is presumed to play important roles in T cell function. In this study, Znhit1, a member of a new zinc finger protein family defined by a conserved Zf-HIT domain, induced arrest in the G1-phase of the cell cycle in NIH/3T3 cells. Of the G1 cell cycle factors examined, the expression of CDK6 was found to be strongly down-regulated by Znhit1 via transcriptional repression. This effect may have correlations with the decreased acetylation level of histone H4 in the CDK6 promoter region. In addition, considering that CDK6 expression predominates in T cells, the negative regulatory role of Znhit1 in TCR-induced T cell proliferation was validated using transgenic mice. These findings identified Znhit1 as a CDK6 regulator that plays an important role in cell proliferation. (C) 2009 Elsevier Inc. All rights reserved.
学科主题	Biochemistry & Molecular Biology; Biophysics
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]	DEPENDENT KINASES ; PROTEIN ; NUCLEAR ; DIFFERENTIATION ; PROLIFERATION ; COACTIVATOR ; TRANSITION ; COMPLEXES ; CANCER ; DOMAIN
收录类别	SCI
语种	英语
WOS记录号	WOS:000267868800028
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1117]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Yang, ZM,Cao, YH,Zhu, XY,et al. Znhit1 causes cell cycle arrest and down-regulates CDK6 expression[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2009,386(1):146-152.
APA	Yang, ZM,Cao, YH,Zhu, XY,Huang, Y,Ding, YQ,&Liu, XL.(2009).Znhit1 causes cell cycle arrest and down-regulates CDK6 expression.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,386(1),146-152.
MLA	Yang, ZM,et al."Znhit1 causes cell cycle arrest and down-regulates CDK6 expression".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 386.1(2009):146-152.