LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling

	LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling
	Gao, YJ; Xiao, QA; Ma, HM; Li, L; Liu, J; Feng, Y; Fang, ZY; Wu, J; Han, XK; Zhang, JH
刊名	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
	2010
卷号	107 期号:44 页码:18892-18897
通讯作者	Ge, GX (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China.,gxge@sibs.ac.cn ; hbji@sibs.ac.cn
英文摘要	LKB1 loss-of-function mutations, observed in similar to 30% of human lung adenocarcinomas, contribute significantly to lung cancer malignancy progression. We show that lysyl oxidase ( LOX), negatively regulated by LKB1 through mTOR-HIF-1 alpha signaling axis, mediates lung cancer progression. Inhibition of LOX activity dramatically alleviates lung cancer malignancy progression. Up-regulated LOX expression triggers excess collagen deposition in Lkb1-deficient lung tumors, and thereafter results in enhanced cancer cell proliferation and invasiveness through activation of beta 1 integrin signaling. High LOX level and activity correlate with poor prognosis and metastasis. Our findings provide evidence of how LKB1 loss of function promotes lung cancer malignancy through remodeling of extracellular matrix microenvironment, and identify LOX as a potential target for disease treatment in lung cancer patients.
学科主题	Science & Technology - Other Topics
类目[WOS]	Multidisciplinary Sciences
关键词[WOS]	PEUTZ-JEGHERS-SYNDROME ; TARGETED THERAPIES ; TUMOR-SUPPRESSOR ; BREAST-CANCER ; MUTATIONS ; METASTASIS ; ADENOCARCINOMA ; SPECIFICITY ; PHENOTYPE ; PATHWAYS
收录类别	SCI
语种	英语
WOS记录号	WOS:000283749000031
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1098]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Gao, YJ,Xiao, QA,Ma, HM,et al. LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2010,107(44):18892-18897.
APA	Gao, YJ.,Xiao, QA.,Ma, HM.,Li, L.,Liu, J.,...&Ji, HB.(2010).LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,107(44),18892-18897.
MLA	Gao, YJ,et al."LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107.44(2010):18892-18897.