Retinoic acid regulates bone morphogenic protein signal duration by promoting the degradation of phosphorylated Smad1

	Retinoic acid regulates bone morphogenic protein signal duration by promoting the degradation of phosphorylated Smad1
	Sheng, NY; Xie, ZH; Wang, C; Bai, G; Zhang, KJ; Zhu, QQ; Song, JG; Guillemot, F; Chen, YG; Lin, AN
刊名	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
	2010
卷号	107 期号:44 页码:18886-18891
通讯作者	Jing, NH (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Shanghai 200031, Peoples R China.,njing@sibs.ac.cn
英文摘要	The proper function of the bone morphogenic protein (BMP) pathway during embryonic development and organ maintenance requires its communication with other signaling pathways. Unlike the well-documented regulation of the BMP pathway by FGF/MAPK and Wnt/GSK3 signals, cross-talk between BMP/Smad and retinoic acid (RA)/RA receptor (RAR) pathways is poorly understood. Here, we show that RA represses BMP signal duration by reducing the level of phosphorylated Smad1 (pSmad1). Through its nuclear receptor-mediated transcription, RA enhances the interaction between pSmad1 and its ubiquitin E3 ligases, thereby promoting pSmad1 ubiquitination and proteasomal degradation. This regulation depends on the RA-increased Gadd45 expression and MAPK activation. During the neural development in chicken embryo, the RA/RAR pathway also suppresses BMP signaling to antagonize BMP-regulated proliferation and differentiation of neural progenitor cells. Furthermore, this cross-talk between RA and BMP pathways is involved in the proper patterning of dorsal neural tube of chicken embryo. Our results reveal a mechanism by which RA suppresses BMP signaling through regulation of pSmad1 stability.
学科主题	Science & Technology - Other Topics
类目[WOS]	Multidisciplinary Sciences
关键词[WOS]	E3 UBIQUITIN LIGASES ; DORSAL SPINAL-CORD ; TGF-BETA ; NERVOUS-SYSTEM ; TRANSCRIPTIONAL ACTIVATION ; CELL-TYPES ; BMP ; RECEPTORS ; PATHWAYS ; FAMILY
收录类别	SCI
语种	英语
WOS记录号	WOS:000283749000030
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1097]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Sheng, NY,Xie, ZH,Wang, C,et al. Retinoic acid regulates bone morphogenic protein signal duration by promoting the degradation of phosphorylated Smad1[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2010,107(44):18886-18891.
APA	Sheng, NY.,Xie, ZH.,Wang, C.,Bai, G.,Zhang, KJ.,...&Jing, NH.(2010).Retinoic acid regulates bone morphogenic protein signal duration by promoting the degradation of phosphorylated Smad1.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,107(44),18886-18891.
MLA	Sheng, NY,et al."Retinoic acid regulates bone morphogenic protein signal duration by promoting the degradation of phosphorylated Smad1".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107.44(2010):18886-18891.