Lung Adenocarcinoma From East Asian Never-Smokers Is a Disease Largely Defined by Targetable Oncogenic Mutant Kinases

	Lung Adenocarcinoma From East Asian Never-Smokers Is a Disease Largely Defined by Targetable Oncogenic Mutant Kinases
	Sun, YH; Ren, Y; Fang, ZY; Li, CG; Fang, R; Gao, B; Han, XK; Tian, WD; Pao, W; Chen, HQ
刊名	JOURNAL OF CLINICAL ONCOLOGY
	2010
卷号	28 期号:30 页码:4616-4620
通讯作者	Chen, HQ (reprint author), Fudan Univ, Shanghai Canc Hosp, Shanghai Med Sch, Rd Dongan 270, Shanghai 200032, Peoples R China.,hqchen1@yahoo.com
英文摘要	Purpose To determine the proportion of lung adenocarcinomas from East Asian never-smokers who harbor known oncogenic driver mutations. Patients and Methods In this surgical series, 52 resected lung adenocarcinomas from never-smokers (< 100 cigarettes in a lifetime) at a single institution (Fudan University, Shanghai, China) were analyzed concurrently for mutations in EGFR, KRAS, NRAS, HRAS, HER2, BRAF, ALK, PIK3CA, TP53 and LKB1. Results Forty-one tumors harbored EGFR mutations, three harbored EML4-ALK fusions, two harbored HER2 insertions, and one harbored a KRAS mutation. All mutations were mutually exclusive. Thus, 90% (47 of 52; 95% CI, 0.7896 to 0.9625) of lung adenocarcinomas from never-smokers were found to harbor well-known oncogenic mutations in just four genes. No BRAF, NRAS, HRAS, or LKB1 mutations were detected, while 15 had TP53 mutations. Four tumors contained PIK3CA mutations, always together with EGFR mutations. Conclusion To our knowledge, this study represents the first comprehensive and concurrent analysis of major recurrent oncogenic mutations found in a large cohort of lung adenocarcinomas from East Asian never-smokers. Since drugs are now available that target mutant EGFR, HER2, and ALK, respectively, this result indicates that prospective mutation testing in these patients should successfully assign a targeted therapy in the majority of cases.
学科主题	Oncology
类目[WOS]	Oncology
关键词[WOS]	FACTOR RECEPTOR MUTATIONS ; SMOKING HISTORY ; CANCER PATIENTS ; GEFITINIB ; EGFR ; GENE ; EML4-ALK ; TUMORS
收录类别	SCI
语种	英语
WOS记录号	WOS:000283056400030
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1094]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Sun, YH,Ren, Y,Fang, ZY,et al. Lung Adenocarcinoma From East Asian Never-Smokers Is a Disease Largely Defined by Targetable Oncogenic Mutant Kinases[J]. JOURNAL OF CLINICAL ONCOLOGY,2010,28(30):4616-4620.
APA	Sun, YH.,Ren, Y.,Fang, ZY.,Li, CG.,Fang, R.,...&Ji, HB.(2010).Lung Adenocarcinoma From East Asian Never-Smokers Is a Disease Largely Defined by Targetable Oncogenic Mutant Kinases.JOURNAL OF CLINICAL ONCOLOGY,28(30),4616-4620.
MLA	Sun, YH,et al."Lung Adenocarcinoma From East Asian Never-Smokers Is a Disease Largely Defined by Targetable Oncogenic Mutant Kinases".JOURNAL OF CLINICAL ONCOLOGY 28.30(2010):4616-4620.