AMP-activated protein kinase is required for induction of apoptosis and epithelial-to-mesenchymal transition

	AMP-activated protein kinase is required for induction of apoptosis and epithelial-to-mesenchymal transition
	Wang, XD; Pan, XC; Song, JG
刊名	CELLULAR SIGNALLING
	2010
卷号	22 期号:11 页码:1790-1797
关键词	AMP-activated protein kinase TGF-beta Epithelial-to-mesenchymal transition Apoptosis
通讯作者	Song, JG (reprint author), 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,jgsong@sibs.ac.cn
英文摘要	AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase which has been implicated in the regulation of cellular energy homeostasis. Relatively very little is known about its role in other cellular processes. We observed that AMPK-alpha can be activated by transforming growth factor-beta 1 (TGF-beta 1) in mouse hepatocytes. Inhibition of AMPK by Compound C, a selective AMPK-alpha inhibitor, inhibited TGF-beta 1-induced apoptosis and EMT in hepatocytes. In addition, overexpression of a dominant-negative form of AMPK-alpha subunit also suppressed TGF-beta 1-induced EMT and apoptosis in AML12 cells. Furthermore, inhibition of AMPK suppressed TGF-beta 1-induced Smad3 transcriptional activity. This study indicates that AMPK is able to modulate Smad3 transcriptional activity, which plays an important role in TGF-beta 1-induced apoptosis and EMT. (C) 2010 Elsevier Inc. All rights reserved.
学科主题	Cell Biology
类目[WOS]	Cell Biology
关键词[WOS]	GROWTH-FACTOR-BETA ; FATTY-ACID OXIDATION ; TGF-BETA ; TUMOR SUPPRESSION ; LIVER ; FIBROSIS ; METABOLISM ; UPSTREAM ; PATHWAY ; CELLS
收录类别	SCI
语种	英语
WOS记录号	WOS:000281463500022
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1069]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Wang, XD,Pan, XC,Song, JG. AMP-activated protein kinase is required for induction of apoptosis and epithelial-to-mesenchymal transition[J]. CELLULAR SIGNALLING,2010,22(11):1790-1797.
APA	Wang, XD,Pan, XC,&Song, JG.(2010).AMP-activated protein kinase is required for induction of apoptosis and epithelial-to-mesenchymal transition.CELLULAR SIGNALLING,22(11),1790-1797.
MLA	Wang, XD,et al."AMP-activated protein kinase is required for induction of apoptosis and epithelial-to-mesenchymal transition".CELLULAR SIGNALLING 22.11(2010):1790-1797.