SWR1 Complex Poises Heterochromatin Boundaries for Antisilencing Activity Propagation

	SWR1 Complex Poises Heterochromatin Boundaries for Antisilencing Activity Propagation
	Zhou, BO; Wang, SS; Xu, LX; Meng, FL; Xuan, YJ; Duan, YM; Wang, JY; Hu, H; Dong, XC; Ding, JP
刊名	MOLECULAR AND CELLULAR BIOLOGY
	2010
卷号	30 期号:10 页码:2391-2400
通讯作者	Zhou, JQ (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,jqzhou@sibs.ac.cn
英文摘要	In eukaryotes, chromosomal processes are usually modulated through chromatin-modifying complexes that are dynamically targeted to specific regions of chromatin. In this study, we show that the chromatin-remodeling complex SWR1 (SWR1-C) uses a distinct strategy to regulate heterochromatin spreading. Swr1 binds in a stable manner near heterochromatin to prepare specific chromosomal regions for H2A.Z deposition, which can be triggered by NuA4-mediated acetylation of histone H4. We also demonstrate through experiments with Swc4, a module shared by NuA4 and SWR1-C, that the coupled actions of NuA4 and SWR1-C lead to the efficient incorporation of H2A.Z into chromatin and thereby synergize heterochromatin boundary activity. Our results support a model where SWR1-C resides at the heterochromatin boundary to maintain and amplify antisilencing activity of histone H4 acetylation through incorporating H2A.Z into chromatin.
学科主题	Biochemistry & Molecular Biology; Cell Biology
类目[WOS]	Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]	CHROMATIN REMODELING COMPLEX ; HISTONE VARIANT H2A.Z ; SACCHAROMYCES-CEREVISIAE ; MODIFYING COMPLEXES ; SILENT CHROMATIN ; H4 ACETYLATION ; SANT DOMAIN ; NUA4 ; ACETYLTRANSFERASE ; YEAST
收录类别	SCI
语种	英语
WOS记录号	WOS:000277040900008
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1063]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Zhou, BO,Wang, SS,Xu, LX,et al. SWR1 Complex Poises Heterochromatin Boundaries for Antisilencing Activity Propagation[J]. MOLECULAR AND CELLULAR BIOLOGY,2010,30(10):2391-2400.
APA	Zhou, BO.,Wang, SS.,Xu, LX.,Meng, FL.,Xuan, YJ.,...&Zhou, JQ.(2010).SWR1 Complex Poises Heterochromatin Boundaries for Antisilencing Activity Propagation.MOLECULAR AND CELLULAR BIOLOGY,30(10),2391-2400.
MLA	Zhou, BO,et al."SWR1 Complex Poises Heterochromatin Boundaries for Antisilencing Activity Propagation".MOLECULAR AND CELLULAR BIOLOGY 30.10(2010):2391-2400.