Mechanistic insights into acquired drug resistance in epidermal growth factor receptor mutation-targeted lung cancer therapy

	Mechanistic insights into acquired drug resistance in epidermal growth factor receptor mutation-targeted lung cancer therapy
	Ji, HB
刊名	CANCER SCIENCE
	2010
卷号	101 期号:9 页码:1933-1938
通讯作者	Ji, HB (reprint author), Chinese Acad Sci, Mol Cell Biol Lab, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai, Peoples R China.,hbji@sibs.ac.cn
英文摘要	Oncogenic mutation of epidermal growth factor receptor kinase domain is strongly associated with clinical response to tyrosine kinase inhibitors in non-small-cell lung carcinoma. Despite an initial encouraging response, patients eventually develop drug resistance and relapse. Great efforts have been made to identify the molecular mechanisms of drug resistance. With the recognition of cancer as a whole complex system, here it is proposed that cancer may evolve drug resistance in a cancer-cell-autonomous manner as well as a non-cancer-cell-autonomous manner. The former mainly arises at three levels: the robustness of the epidermal growth factor receptor signaling network; cancer epigenetic changes; or cancer genetic alteration, which may be dependent on the therapeutics methods and treatment duration. As cancer stroma plays an essential role in lung cancerigenesis, we further discuss the potential mechanisms for drug resistance development in a non-cancer-cell-autonomous manner, which may arise from the interaction between cancer cells and cancer stroma, including stromal cells and extracellular matrix. (Cancer Sci 2010).
学科主题	Oncology
类目[WOS]	Oncology
关键词[WOS]	TYROSINE KINASE INHIBITORS ; PROTEIN-COUPLED RECEPTORS ; HISTONE DEACETYLASE INHIBITORS ; EGF RECEPTOR ; MET AMPLIFICATION ; GENE MUTATION ; GEFITINIB RESISTANCE ; ACTIVATING MUTATIONS ; ANTICANCER THERAPY ; SOMATIC MUTATIONS
收录类别	SCI
语种	英语
WOS记录号	WOS:000281135500002
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1045]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Ji, HB. Mechanistic insights into acquired drug resistance in epidermal growth factor receptor mutation-targeted lung cancer therapy[J]. CANCER SCIENCE,2010,101(9):1933-1938.
APA	Ji, HB.(2010).Mechanistic insights into acquired drug resistance in epidermal growth factor receptor mutation-targeted lung cancer therapy.CANCER SCIENCE,101(9),1933-1938.
MLA	Ji, HB."Mechanistic insights into acquired drug resistance in epidermal growth factor receptor mutation-targeted lung cancer therapy".CANCER SCIENCE 101.9(2010):1933-1938.