Interferon Regulatory Factor 3, A Pivotal Transcription Factor for Host Antiviral Responses

	Interferon Regulatory Factor 3, A Pivotal Transcription Factor for Host Antiviral Responses
	Liu, X; Shi, HX; Wang, C
刊名	PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
	2010
卷号	37 期号:8 页码:817-825
关键词	interferon regulatory factor 3 transcription regulation post-translational modification signal transduction antiviral mechanism
通讯作者	Wang, C (reprint author), Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China.,cwang01@sibs.ac.cn
英文摘要	The innate immune system is the first line of host defense against viruses. Type I interferons (IFNs), the vital antiviral cytokines, play a critical role in establishing host antiviral state. Induction of type I IFN requires the formation of a multi-protein enhanceosome, including three families of key transcription factors (NF-kappa B, IRF3/7, and ATF-2/c-Jun). Transcription factor IRF3 (interferon regulatory factor 3) plays a pivotal role and is tightly regulated in this process. Recently, much progress has been made on cellular signal transduction and regulation of IRF3. Relevant advances in IRF3 biology were summarized with respect to its structure, function and regulatory mechanisms.
学科主题	Biochemistry & Molecular Biology; Biophysics
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]	INNATE IMMUNE-RESPONSE ; DOUBLE-STRANDED-RNA ; MEDIATED DEGRADATION ; VIRUS-INFECTION ; IN-VIVO ; NEGATIVE REGULATION ; CRYSTAL-STRUCTURE ; GENE-EXPRESSION ; ACTIVATION ; IRF-3
收录类别	SCI
语种	中文
WOS记录号	WOS:000281193900001
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1038]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Liu, X,Shi, HX,Wang, C. Interferon Regulatory Factor 3, A Pivotal Transcription Factor for Host Antiviral Responses[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2010,37(8):817-825.
APA	Liu, X,Shi, HX,&Wang, C.(2010).Interferon Regulatory Factor 3, A Pivotal Transcription Factor for Host Antiviral Responses.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,37(8),817-825.
MLA	Liu, X,et al."Interferon Regulatory Factor 3, A Pivotal Transcription Factor for Host Antiviral Responses".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 37.8(2010):817-825.