MAPK signaling in inflammation-associated cancer development

	MAPK signaling in inflammation-associated cancer development
	Huang, PY; Han, JH; Hui, LJ
刊名	PROTEIN & CELL
	2010
卷号	1 期号:3 页码:218-226
通讯作者	Han, JH (reprint author), Xiamen Univ, Sch Life Sci, Minist Educ Cell Biol & Tumor Cell Engn, Key Lab, Xiamen 361005, Peoples R China.,jhan@xmu.edu.cn ; ljhui@sibs.ac.cn
英文摘要	Mitogen-activated protein (MAP) kinases comprise a family of protein-serine/threonine kinases, which are highly conserved in protein structures from unicellular eukaryotic organisms to multicellular organisms, including mammals. These kinases, including ERKs, JNKs and p38s, are regulated by a phosphorelay cascade, with a prototype of three protein kinases that sequentially phosphorylate one another. MAPKs transduce extracellular signals into a variety of cellular processes, such as cell proliferation, survival, death, and differentiation. Consistent with their essential cellular functions, MAPKs have been shown to play critical roles in embryonic development, adult tissue homeostasis and various pathologies. In this review, we discuss recent findings that reveal the profound impact of these pathways on chronic inflammation and, particularly, inflammation-associated cancer development.
学科主题	Cell Biology
类目[WOS]	Cell Biology
收录类别	SCI
语种	英语
WOS记录号	WOS:000208510600004
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/980]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Huang, PY,Han, JH,Hui, LJ. MAPK signaling in inflammation-associated cancer development[J]. PROTEIN & CELL,2010,1(3):218-226.
APA	Huang, PY,Han, JH,&Hui, LJ.(2010).MAPK signaling in inflammation-associated cancer development.PROTEIN & CELL,1(3),218-226.
MLA	Huang, PY,et al."MAPK signaling in inflammation-associated cancer development".PROTEIN & CELL 1.3(2010):218-226.