Slit-Robo signaling mediates lymphangiogenesis and promotes tumor lymphatic metastasis

	Slit-Robo signaling mediates lymphangiogenesis and promotes tumor lymphatic metastasis
	Yang, XM; Han, HX; Sui, F; Dai, YM; Chen, M; Geng, JG
刊名	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
	2010
卷号	396 期号:2 页码:571-577
关键词	Slit Robo Lymphangiogenesis Tumor metastasis beta-Cell carcinoma
通讯作者	Geng, JG (reprint author), Univ Minnesota, Sch Med, Dept Med, Vasc Biol Ctr,Div Hematol Oncol & Transplantat, MMC 480,420 Delaware St SE, Minneapolis, MN 55455 USA.,genglab@gmail.com
英文摘要	The Slit family of guidance cues binds to Roundabout (Robo) receptors to modulate neuronal, leukocytic, and endothelial migration. Slit-Robo signaling had been reported to function as chemoattractive signal for vascular endothelial cells during angiogenesis. In this study, we found that Robo1 was expressed in lymphatic endothelial cells to mediate the migration and tube formation of these cells upon Slit2 stimulation, which were specifically inhibited by the function-blocking antibody R5 to Slit2/Robo1 interaction. To further explore the lymphangiogenic effect and significance mediated by Slit-Robo signaling, we intercrossed Slit2 transgenic mice with a non-metastatic RIP1-Tag2 mouse tumor model, and found that transgenic overexpression of Slit2 significantly enhanced tumor lymphangiogenesis and subsequently promoted mesenteric lymph node metastasis of pancreatic islet tumors. Taken together, our findings reveal that through interacting with Robo1, Slit2 is a novel and potent lymphangiogenic factor and contributes to tumor lymphatic metastasis. (C) 2010 Elsevier Inc. All rights reserved.
学科主题	Biochemistry & Molecular Biology; Biophysics
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]	IN-VIVO ; GROWTH ; ANGIOGENESIS ; CELLS ; MECHANISMS ; GUIDANCE ; MODELS
收录类别	SCI
语种	英语
WOS记录号	WOS:000278658000068
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/947]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Yang, XM,Han, HX,Sui, F,et al. Slit-Robo signaling mediates lymphangiogenesis and promotes tumor lymphatic metastasis[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2010,396(2):571-577.
APA	Yang, XM,Han, HX,Sui, F,Dai, YM,Chen, M,&Geng, JG.(2010).Slit-Robo signaling mediates lymphangiogenesis and promotes tumor lymphatic metastasis.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,396(2),571-577.
MLA	Yang, XM,et al."Slit-Robo signaling mediates lymphangiogenesis and promotes tumor lymphatic metastasis".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 396.2(2010):571-577.