Influence of hepatic artery occlusion on tumor growth and metastatic potential in a human orthotopic hepatoma nude mouse model: Relevance of epithelial-mesenchymal transition

	Influence of hepatic artery occlusion on tumor growth and metastatic potential in a human orthotopic hepatoma nude mouse model: Relevance of epithelial-mesenchymal transition
	Liu, L; Ren, ZG; Shen, Y; Zhu, XD; Zhang, W; Xiong, W; Qin, Y; Tang, ZY
刊名	CANCER SCIENCE
	2010
卷号	101 期号:1 页码:120-128
通讯作者	Tang, ZY (reprint author), Fudan Univ, Liver Canc Inst, Shanghai 200433, Peoples R China.,zytang88@163.com
英文摘要	Hepatic artery ligation (HAL), transarterial embolization (TAE), and transarterial chemoembolization (TACE) have been treatment choices for unresectable hepatocellular carcinoma (HCC). Obstruction of tumor blood supply is one of the most important mechanisms of these therapeutics measures. Here we introduced HAL into a metastatic human HCC orthotopic nude mouse model (using MHCC97L and HepG2 cell lines) to examine the effects of hepatic blood flow obstruction on the metastatic potential of hepatic tumor cells, and to investigate the mechanisms underlying these effects. Our results indicated that HAL inhibited tumor growth but concomitantly elicited tumor adaptation and progression, with increased potential for invasion and distant metastases. The underlying proinvasive mechanism of HAL appeared to be associated with enhanced intratumoral hypoxia and epithelial-mesenchymal transition (EMT) due to hypoxia. This was in accord with the in vitro response of MHCC97L and HepG2 cells to hypoxia. The therapeutic effects of HAL could be enhanced by the phosphatidyl inositol 3-kinase (PI3K) inhibitor LY294002, through arrest of EMT in hepatic tumor cells. It could be useful in the development of mechanism-based combination therapies to enhance the initial antitumor response. (Cancer Sci 2009).
学科主题	Oncology
类目[WOS]	Oncology
关键词[WOS]	HEPATOCELLULAR-CARCINOMA ; TRANSARTERIAL CHEMOEMBOLIZATION ; STEM-CELLS ; CANCER ; ANGIOGENESIS ; HYPOXIA ; PROGRESSION ; EMBOLIZATION ; THERAPY ; MICE
收录类别	SCI
语种	英语
WOS记录号	WOS:000272631500017
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/929]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Liu, L,Ren, ZG,Shen, Y,et al. Influence of hepatic artery occlusion on tumor growth and metastatic potential in a human orthotopic hepatoma nude mouse model: Relevance of epithelial-mesenchymal transition[J]. CANCER SCIENCE,2010,101(1):120-128.
APA	Liu, L.,Ren, ZG.,Shen, Y.,Zhu, XD.,Zhang, W.,...&Tang, ZY.(2010).Influence of hepatic artery occlusion on tumor growth and metastatic potential in a human orthotopic hepatoma nude mouse model: Relevance of epithelial-mesenchymal transition.CANCER SCIENCE,101(1),120-128.
MLA	Liu, L,et al."Influence of hepatic artery occlusion on tumor growth and metastatic potential in a human orthotopic hepatoma nude mouse model: Relevance of epithelial-mesenchymal transition".CANCER SCIENCE 101.1(2010):120-128.