Oncolytic adenovirus expressing interleukin-18 induces significant antitumor effects against melanoma in mice through inhibition of angiogenesis

	Oncolytic adenovirus expressing interleukin-18 induces significant antitumor effects against melanoma in mice through inhibition of angiogenesis
	Zheng, JN; Pei, DS; Mao, LJ; Liu, XY; Sun, FH; Zhang, BF; Liu, YQ; Liu, JJ; Li, W; Han, D
刊名	CANCER GENE THERAPY
	2010
卷号	17 期号:1 页码:28-36
关键词	IL-18 oncolytic adenovirus melanoma VEGF CD34
通讯作者	Zheng, JN (reprint author), Xuzhou Med Coll, Affiliated Hosp, Lab Urol, 99 W Huai Hai Rd, Xuzhou 221002, Jiangsu, Peoples R China.,jnzheng@xzmc.edu.cn
英文摘要	It has been shown that interleukin 18 (IL-18) exerts antitumor activity. In this study, we investigated whether oncolytic adenovirus-mediated gene transfer of IL-18 could induce strong antitumor activity. A tumor-selective replicating adenovirus expressing IL-18 (ZD55-IL-18) was constructed by insertion of an IL-18 expression cassette into the ZD55 vector, which is based on deletion of the adenoviral E1B 55-kDa gene. It has been shown that ZD55-IL-18 exerted a strong cytopathic effect and significant apoptosis in tumor cells. ZD55-IL-18 significantly decreased vascular endothelial growth factor and CD34 expression in the melanoma cells. Treatment of established tumors with ZD55-IL-18 showed much stronger antitumor activity than that induced by ZD55-EGFP (enhanced green fluorescent protein) or Ad-IL-18. These data indicated that oncolytic adenovirus expressing IL-18 could exert potential antitumor activity through inhibition of angiogenesis and offer a novel approach to melanoma therapy. Cancer Gene Therapy (2010) 17, 28-36; doi: 10.1038/cgt.2009.38; published online 5 June 2009
学科主题	Biotechnology & Applied Microbiology; Oncology; Genetics & Heredity; Research & Experimental Medicine
类目[WOS]	Biotechnology & Applied Microbiology ; Oncology ; Genetics & Heredity ; Medicine, Research & Experimental
关键词[WOS]	ENDOTHELIAL GROWTH-FACTOR ; REPLICATION-SELECTIVE ADENOVIRUS ; RECOMBINANT HUMAN INTERLEUKIN-12 ; INTERFERON-GAMMA PRODUCTION ; RENAL-CELL CARCINOMA ; FAS-LIGAND ; IFN-GAMMA ; T-CELLS ; INTRAVENOUS-INFUSION ; SYNGENEIC MICE
收录类别	SCI
语种	英语
WOS记录号	WOS:000272819100004
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/928]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Zheng, JN,Pei, DS,Mao, LJ,et al. Oncolytic adenovirus expressing interleukin-18 induces significant antitumor effects against melanoma in mice through inhibition of angiogenesis[J]. CANCER GENE THERAPY,2010,17(1):28-36.
APA	Zheng, JN.,Pei, DS.,Mao, LJ.,Liu, XY.,Sun, FH.,...&Han, D.(2010).Oncolytic adenovirus expressing interleukin-18 induces significant antitumor effects against melanoma in mice through inhibition of angiogenesis.CANCER GENE THERAPY,17(1),28-36.
MLA	Zheng, JN,et al."Oncolytic adenovirus expressing interleukin-18 induces significant antitumor effects against melanoma in mice through inhibition of angiogenesis".CANCER GENE THERAPY 17.1(2010):28-36.