Urinary Pigment Epithelium-Derived Factor as a Marker of Diabetic Nephropathy

	Urinary Pigment Epithelium-Derived Factor as a Marker of Diabetic Nephropathy
	Chen, HB; Zheng, Z; Li, RX; Lu, JX; Bao, YQ; Ying, XF; Zeng, R; Jia, WP
刊名	AMERICAN JOURNAL OF NEPHROLOGY
	2010
卷号	32 期号:1 页码:47-56
关键词	Diabetic nephropathies Pigment epithelium-derived factor Microalbuminuria Angiotensin II type 1 receptor antagonist
通讯作者	Jia, WP (reprint author), Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Endocrinol & Metab,Shanghai Key Lab Diabet M, Shanghai Clin Ctr Diabet,Shanghai Diabet Inst, Shanghai 200233, Peoples R China.,wpjia@sjtu.edu.cn
英文摘要	Background: Pigment epithelium-derived factor (PEDF), a serine protease inhibitor, regulates extracellular matrix production in the kidney. We sought the association between urinary PEDF (uPEDF) and development of nephropathy among patients with type 2 diabetes (T2DM). Methods: Two human studies were performed in which uPEDF was determined by ELISA. These studies included (1) a cross-sectional study of T2DM (n = 228) and healthy controls (n = 49) and (2) a longitudinal study of hypertensive T2DM with microalbuminuria (MA; n = 42) treated with irbesartan for 6 months. An animal study was performed in which PEDF was measured in the kidney and urine samples of control rats, rats rendered diabetic with streptozotocin that were also fed a high-fat diet, and diabetic rats treated with irbesartan for 3 months. Results: Cross-sectional study: compared to controls, uPEDF was significantly higher in patients with diabetic nephropathy. uPEDF independently correlated with MA. In the MA group, uPEDF in patients with diabetic retinopathy was significantly higher than that in patients without diabetic retinopathy. Longitudinal study: irbesartan significantly decreased uPEDF in T2DM with MA. Animal study: in diabetic rats, increased PEDF was observed in both the urine and kidney samples. uPEDF showed a significant correlation with the expression of PEDF in the kidney. Irbesartan could significantly decrease the PEDF expression in the kidneys of diabetic rats as well as uPEDF. Conclusion: uPEDF may serve as a novel marker for screening for nephropathy among patients with T2DM and monitoring the response to therapy. Copyright (C) 2010 S. Karger AG, Basel
学科主题	Urology & Nephrology
类目[WOS]	Urology & Nephrology
关键词[WOS]	STREPTOZOTOCIN-TREATED RAT ; INSULIN-RESISTANCE ; FACTOR PEDF ; EXPRESSION ; MODEL ; IDENTIFICATION ; RETINOPATHY ; NEPHRIN ; DISEASE ; CELLS
收录类别	SCI
语种	英语
WOS记录号	WOS:000278684800007
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/924]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Chen, HB,Zheng, Z,Li, RX,et al. Urinary Pigment Epithelium-Derived Factor as a Marker of Diabetic Nephropathy[J]. AMERICAN JOURNAL OF NEPHROLOGY,2010,32(1):47-56.
APA	Chen, HB.,Zheng, Z.,Li, RX.,Lu, JX.,Bao, YQ.,...&Jia, WP.(2010).Urinary Pigment Epithelium-Derived Factor as a Marker of Diabetic Nephropathy.AMERICAN JOURNAL OF NEPHROLOGY,32(1),47-56.
MLA	Chen, HB,et al."Urinary Pigment Epithelium-Derived Factor as a Marker of Diabetic Nephropathy".AMERICAN JOURNAL OF NEPHROLOGY 32.1(2010):47-56.