ETHANOL-INDUCED NEURODEGENERATION IN NRSF/REST NEURONAL CONDITIONAL KNOCKOUT MICE

	ETHANOL-INDUCED NEURODEGENERATION IN NRSF/REST NEURONAL CONDITIONAL KNOCKOUT MICE
	Cai, L; Bian, M; Liu, M; Sheng, Z; Suo, H; Wang, Z; Huang, F; Fei, J
刊名	NEUROSCIENCE
	2011
卷号	181 期号:1 页码:196-205
关键词	nrsf conditional knockout ethanol apoptosis caspase-3 fetal alcohol syndrome
通讯作者	Fei, J (reprint author), Tongji Univ, Sch Life Sci & Technol, 1239 Shipping Rd, Shanghai 200092, Peoples R China.,huangf@shmu.edu.cn
英文摘要	The transcription regulator, neuron-restrictive silencer factor (NRSF), also known as repressor element-1 silencing transcription factor (REST), plays an important role in neurogenesis and various neuronal diseases such as ischaemia, epilepsy, and Huntington's disease. In these disease processes, neuronal loss is associated with abnormal expression and/or localization of NRSF. Previous studies have demonstrated that NRSF regulates the effect of ethanol on neuronal cells in vitro, however, the role of NRSF in ethanol-induced neuronal cell death remains unclear. We generated nrsf conditional knockout mice using the Cre-IoxP system to disrupt neuronal expression of nrsf and its truncated forms. At postnatal day 6, ethanol significantly increased the expression of REST4, a neuron-specific truncated form of NRSF, in the brains of wild type mice, and this effect was diminished in nrsf conditional knockout mice. The apoptotic effect of ethanol was pronounced in multiple brain regions of nrsf conditional mutant mice. These results indicate that NRSF, specifically REST4, may protect the developing brain from ethanol, and provide new evidence that NRSF can be a therapeutic target in foetal alcohol syndrome (FAS). (C) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.
学科主题	Neurosciences & Neurology
类目[WOS]	Neurosciences
关键词[WOS]	INDUCED APOPTOTIC NEURODEGENERATION ; DEVELOPING MOUSE-BRAIN ; FETAL ALCOHOL SYNDROME ; PURKINJE-CELL LOSS ; GENE-EXPRESSION ; IN-VIVO ; GROWTH SPURT ; TARGET GENES ; CEREBELLAR PURKINJE ; BETA-GALACTOSIDASE
收录类别	SCI
语种	英语
WOS记录号	WOS:000289607000018
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/918]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Cai, L,Bian, M,Liu, M,et al. ETHANOL-INDUCED NEURODEGENERATION IN NRSF/REST NEURONAL CONDITIONAL KNOCKOUT MICE[J]. NEUROSCIENCE,2011,181(1):196-205.
APA	Cai, L.,Bian, M.,Liu, M.,Sheng, Z.,Suo, H.,...&Fei, J.(2011).ETHANOL-INDUCED NEURODEGENERATION IN NRSF/REST NEURONAL CONDITIONAL KNOCKOUT MICE.NEUROSCIENCE,181(1),196-205.
MLA	Cai, L,et al."ETHANOL-INDUCED NEURODEGENERATION IN NRSF/REST NEURONAL CONDITIONAL KNOCKOUT MICE".NEUROSCIENCE 181.1(2011):196-205.