SRMBUILDER: A USER-FRIENDLY TOOL FOR SELECTED REACTION MONITORING DATA ANALYSIS

	SRMBUILDER: A USER-FRIENDLY TOOL FOR SELECTED REACTION MONITORING DATA ANALYSIS
	Sheng, QH; Wu, CC; Su, ZD; Zeng, R
刊名	JOURNAL OF BIOINFORMATICS AND COMPUTATIONAL BIOLOGY
	2011
卷号	9 期号:1 页码:51-62
关键词	SRM SRMBuilder quantification mass spectrometry targeted proteomics
通讯作者	Sheng, QH (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, Shanghai, Peoples R China.,qhsheng@sibs.ac.cn ; ccwu@sibs.ac.cn ; suzhiduan@sibs.ac.cn ; zr@sibs.ac.cn
英文摘要	With high sensitivity and reproducibility, selected reaction monitoring (SRM) has become increasingly popular in proteome research for targeted quantification of low abundance proteins and post translational modification. SRM is also well accepted in other mass-spectrometry based research areas such as lipidomics and metabolomics, which necessitates the development of easy-to-use software for both post-acquisition SRM data analysis and quantification result validation. Here, we introduce a software tool SRMBuilder, which can automatically parse SRM data in multiple file formats, assign transitions to compounds, match light/heavy transition/compound pairs and provide a user-friendly graphic interface to manually validate the quantification result at transition/compound/sample level. SRMBuilder will greatly facilitate processing of the post-acquisition data files and validation of quantification result for SRM. The software can be downloaded for free from http://www.proteomics.ac.cn/software/proteomicstools/index.htm as part of the software suite ProteomicsTools.
学科主题	Biochemistry & Molecular Biology; Computer Science; Mathematical & Computational Biology
类目[WOS]	Biochemical Research Methods ; Computer Science, Interdisciplinary Applications ; Mathematical & Computational Biology
关键词[WOS]	TANDEM MASS-SPECTROMETRY ; PROTEOMICS
收录类别	SCI
语种	英语
WOS记录号	WOS:000299290400005
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/907]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Sheng, QH,Wu, CC,Su, ZD,et al. SRMBUILDER: A USER-FRIENDLY TOOL FOR SELECTED REACTION MONITORING DATA ANALYSIS[J]. JOURNAL OF BIOINFORMATICS AND COMPUTATIONAL BIOLOGY,2011,9(1):51-62.
APA	Sheng, QH,Wu, CC,Su, ZD,&Zeng, R.(2011).SRMBUILDER: A USER-FRIENDLY TOOL FOR SELECTED REACTION MONITORING DATA ANALYSIS.JOURNAL OF BIOINFORMATICS AND COMPUTATIONAL BIOLOGY,9(1),51-62.
MLA	Sheng, QH,et al."SRMBUILDER: A USER-FRIENDLY TOOL FOR SELECTED REACTION MONITORING DATA ANALYSIS".JOURNAL OF BIOINFORMATICS AND COMPUTATIONAL BIOLOGY 9.1(2011):51-62.