Reversible Pore-Structure Evolution in Hollow Silica Nanocapsules: Large Pores for siRNA Delivery and Nanoparticle Collecting

	Reversible Pore-Structure Evolution in Hollow Silica Nanocapsules: Large Pores for siRNA Delivery and Nanoparticle Collecting
	Chen, Y; Chu, C; Zhou, YC; Ru, YF; Chen, HR; Chen, F; He, QJ; Zhang, YL; Zhang, LL; Shi, JL
刊名	SMALL
	2011
卷号	7 期号:20 页码:2935-2944
通讯作者	Zhou, YC (reprint author), Chinese Acad Sci, Shanghai Key Lab Mol Androl, State Key Lab Mol Biol, Inst Biochem & Cell Biol,Shanghai Inst Biol Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,zhouych@sibs.ac.cn ; hrchen@mail.sic.ac.cn ; jlshi@sunm.shcnc.ac.cn
英文摘要	The effective modulation of pore sizes for nanoporous silica nanoparticles still remains a great challenge not satisfactorily solved. In this paper, the pore sizes in the shell of hollow silica nanocapsules are well-tuned by a reversible Si-O bond breakage and reformation process under mildly alkaline conditions (e. g., Na(2)CO(3) solution). The pores in nanosized hollow silica capsules can be modulated from 3.2 nm to larger than 10 nm by a novel, surfactant-directing alkaline-etching (SDAE) strategy. Interestingly, the pores can be fully filled through the regrowth of the dissoluted silicates by bonding to silanols (Si-OH) on the wall surface to generate the nonporous hollow silica nanocapsules. The large-sized pore hollow silica nanocapsules exhibit excellent siRNA-loading capabilities and intracellular transfection efficiencies in vitro. In addition, the large pores in the shell of hollow silica nanocapsules are explored as channels for collecting superparamagnetic, small-sized Fe(3)O(4) nanoparticles as contrast agents for magnetic resonance imaging, initiating a special approach towards pore-size modulation and multifunctionalization of silica-based nanostructural materials for nanobiomedical applications.
学科主题	Chemistry; Science & Technology - Other Topics; Materials Science; Physics
类目[WOS]	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
关键词[WOS]	MESOPOROUS SILICA ; DRUG-DELIVERY ; SHELL STRUCTURE ; SPHERES ; CELL ; CORE ; FABRICATION ; DOXORUBICIN ; PATHWAYS ; EFFICACY
收录类别	SCI
语种	英语
WOS记录号	WOS:000296183600017
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/882]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Chen, Y,Chu, C,Zhou, YC,et al. Reversible Pore-Structure Evolution in Hollow Silica Nanocapsules: Large Pores for siRNA Delivery and Nanoparticle Collecting[J]. SMALL,2011,7(20):2935-2944.
APA	Chen, Y.,Chu, C.,Zhou, YC.,Ru, YF.,Chen, HR.,...&Shi, JL.(2011).Reversible Pore-Structure Evolution in Hollow Silica Nanocapsules: Large Pores for siRNA Delivery and Nanoparticle Collecting.SMALL,7(20),2935-2944.
MLA	Chen, Y,et al."Reversible Pore-Structure Evolution in Hollow Silica Nanocapsules: Large Pores for siRNA Delivery and Nanoparticle Collecting".SMALL 7.20(2011):2935-2944.