Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus

	Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus
	Zhang, YY; Mao, FF; Lu, Y; Wu, WQ; Zhang, L; Zhao, Y
刊名	CELL RESEARCH
	2011
卷号	21 期号:10 页码:1436-1451
关键词	Cubitus interruptus Drosophila Fused Hedgehog morphogen
通讯作者	Zhao, Y (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China.,rayzhang@sibs.ac.cn ; yunzhao@sibs.ac.cn
英文摘要	The Hedgehog (Hh) family of secreted proteins is essential for development in both vertebrates and invertebrates. As one of main morphogens during metazoan development, the graded Hh signal is transduced across the plasma membrane by Smoothened (Smo) through the differential phosphorylation of its cytoplasmic tail, leading to pathway activation and the differential expression of target genes. However, how Smo transduces the graded Hh signal via the Costal2 (Cos2)/Fused(Fu) complex remains poorly understood. Here we present a model of the cell response to a Hh gradient by translating Smo phosphorylation information to Fu dimerization and Cubitus interruptus (Ci) nuclear localization information. Our findings suggest that the phosphorylated C-terminus of Smo recruits the Cos2/Fu complex to the membrane through the interaction between Smo and Cos2, which further induces Fu dimerization. Dimerized Fu is phosphorylated and transduces the Hh signal by phosphorylating Cos2 and Suppressor of Fu (Su(fu)). We further show that this process promotes the dissociation of the full-length Ci (Ci155) and Cos2 or Su(fu), and results in the translocation of Ci155 into the nucleus, activating the expression of target genes.
学科主题	Cell Biology
类目[WOS]	Cell Biology
关键词[WOS]	KINESIN-RELATED PROTEIN ; GENE-EXPRESSION ; DROSOPHILA ; PHOSPHORYLATION ; COSTAL2 ; PATHWAY ; COMPLEX ; ASSOCIATION ; ACTIVATION ; IDENTIFICATION
收录类别	SCI
语种	英语
WOS记录号	WOS:000295457400008
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/860]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Zhang, YY,Mao, FF,Lu, Y,et al. Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus[J]. CELL RESEARCH,2011,21(10):1436-1451.
APA	Zhang, YY,Mao, FF,Lu, Y,Wu, WQ,Zhang, L,&Zhao, Y.(2011).Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus.CELL RESEARCH,21(10),1436-1451.
MLA	Zhang, YY,et al."Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus".CELL RESEARCH 21.10(2011):1436-1451.