A detective monoclonal antibody recognized conserved epitope of hemagglutinin from H5N1 influenza virus

	A detective monoclonal antibody recognized conserved epitope of hemagglutinin from H5N1 influenza virus
	Zhuang, XX; Sun, YZ; Ling, ZY; Dong, QX; Zhu, JY; Tang, LN; Zhou, YY; Ji, YY; Tian, L; Lin, GM
刊名	COMPTES RENDUS CHIMIE
	2011
卷号	14 期号:9 页码:826-830
关键词	Immunoassays Immunology Proteins Antigens Antibodies
通讯作者	Sun, B (reprint author), Chinese Acad Sci, Inst Pasteur Shanghai, Shanghai 200025, Peoples R China.,cbian@sibs.ac.cn ; bsun@sibs.ac.cn
英文摘要	Monoclonal antibodies are needed for the development of effective, accurate and sensitive immunoassays against the H5N1 avian influenza. Here we report the generation of monoclonal antibodies targeting Escherichia coli expressed hemagglutinin of HA1 domain from H5N1 influenza virus. The monoclonal antibodies can be used to establish a sandwich ELISA assay that is able to detect HA from H5 subtype virus lysate but not from H9 subtype. A subtype-conserved new epitope was also identified which is located between the amino acid residues N80 to A99. This work would be helpful for the development of a diagnosis kit for the H5N1 avian influenza. (C) 2011 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.
学科主题	Chemistry
类目[WOS]	Chemistry, Multidisciplinary
关键词[WOS]	MOLECULE
收录类别	SCI
语种	英语
WOS记录号	WOS:000296953500006
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/847]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Zhuang, XX,Sun, YZ,Ling, ZY,et al. A detective monoclonal antibody recognized conserved epitope of hemagglutinin from H5N1 influenza virus[J]. COMPTES RENDUS CHIMIE,2011,14(9):826-830.
APA	Zhuang, XX.,Sun, YZ.,Ling, ZY.,Dong, QX.,Zhu, JY.,...&Sun, B.(2011).A detective monoclonal antibody recognized conserved epitope of hemagglutinin from H5N1 influenza virus.COMPTES RENDUS CHIMIE,14(9),826-830.
MLA	Zhuang, XX,et al."A detective monoclonal antibody recognized conserved epitope of hemagglutinin from H5N1 influenza virus".COMPTES RENDUS CHIMIE 14.9(2011):826-830.