Sorafenib Inhibits Transforming Growth Factor beta 1-Mediated Epithelial-Mesenchymal Transition and Apoptosis in Mouse Hepatocytes

	Sorafenib Inhibits Transforming Growth Factor beta 1-Mediated Epithelial-Mesenchymal Transition and Apoptosis in Mouse Hepatocytes
	Chen, YL; Lv, J; Ye, XL; Sun, MY; Xu, Q; Liu, CH; Min, LH; Li, HP; Liu, P; Ding, XY
刊名	HEPATOLOGY
	2011
卷号	53 期号:5 页码:1708-1718
通讯作者	Ding, XY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci SIBS, Inst Biochem & Cell Biol, Key Lab Mol Cell Biol, 320 Yueyang Rd, Shanghai 200031, Peoples R China.,liuliver@vip.sina.com ; xyding@sunm.shcnc.ac.cn
英文摘要	Epithelial-mesenchymal transition (EMT) is a physiological process that has been recognized to occur during the progression of an increasingly large number of human diseases, including liver fibrosis, cirrhosis, and hepatocellular carcinoma. The activation of transforming growth factor beta (TGF-beta) signaling is considered a critical event during EMT, and efforts have been made to screen small molecules that interfere with the TGF-beta signaling pathway during EMT. Here we report the identification of sorafenib, a clinical agent that inhibits TGF-beta signaling. When applied to AML12 cells and primary hepatocytes, sorafenib strikingly suppressed TGF-beta 1-induced EMT and apoptosis. Additionally, sorafenib inhibited TGF-beta 1-induced signal transducer and activator of transcription 3 phosphorylation. We further present in vitro evidence that sorafenib ameliorates the proapoptotic and profibrotic effects of TGF-beta 1 in mouse primary hepatocytes, suggesting that this drug exerts a protective effect on hepatocytes and has therapeutic potential for the treatment of liver fibrosis. (HEPATOLOGY 2011;53:1708-1718)
学科主题	Gastroenterology & Hepatology
类目[WOS]	Gastroenterology & Hepatology
关键词[WOS]	TGF-BETA ; LIVER FIBROSIS ; HEPATIC FIBROGENESIS ; MECHANISMS ; CANCER ; CELLS ; TUMOR ; RAT ; TRANSCRIPTION-3 ; SUPPRESSION
收录类别	SCI
语种	英语
WOS记录号	WOS:000289956100031
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/807]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Chen, YL,Lv, J,Ye, XL,et al. Sorafenib Inhibits Transforming Growth Factor beta 1-Mediated Epithelial-Mesenchymal Transition and Apoptosis in Mouse Hepatocytes[J]. HEPATOLOGY,2011,53(5):1708-1718.
APA	Chen, YL.,Lv, J.,Ye, XL.,Sun, MY.,Xu, Q.,...&Ding, XY.(2011).Sorafenib Inhibits Transforming Growth Factor beta 1-Mediated Epithelial-Mesenchymal Transition and Apoptosis in Mouse Hepatocytes.HEPATOLOGY,53(5),1708-1718.
MLA	Chen, YL,et al."Sorafenib Inhibits Transforming Growth Factor beta 1-Mediated Epithelial-Mesenchymal Transition and Apoptosis in Mouse Hepatocytes".HEPATOLOGY 53.5(2011):1708-1718.