Activin C expressed in nociceptive afferent neurons is required for suppressing inflammatory pain

	Activin C expressed in nociceptive afferent neurons is required for suppressing inflammatory pain
	Liu, XJ; Zhang, FX; Liu, H; Li, KC; Lu, YJ; Wu, QF; Li, JY; Wang, B; Wang, Q; Lin, LB
刊名	BRAIN
	2012
卷号	135 期号:1 页码:391-403
关键词	activin C inflammatory pain dorsal root ganglion extracellular signal-regulated kinase
通讯作者	Zhang, X (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, State Key Lab Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,xu.zhang@ion.ac.cn
英文摘要	Emerging evidence suggests that the suppressive modulators released from nociceptive afferent neurons contribute to pain regulation. However, the suppressive modulators expressed in small-diameter neurons of the dorsal root ganglion remain to be further identified. The present study shows that the activin C expressed in small dorsal root ganglion neurons is required for suppressing inflammation-induced nociceptive responses. The expression of activin C in small dorsal root ganglion neurons of rats was markedly downregulated during the early days of peripheral inflammation induced by intraplantar injection of the complete Freund's adjuvant. Intrathecal treatment with the small interfering RNA targeting activin beta C or the antibodies against activin C could enhance the formalin-induced nociceptive responses, and impair the recovery from the complete Freund's adjuvant-induced thermal hyperalgesia. Intrathecally applied activin C could reduce nociceptive responses induced by formalin or complete Freund's adjuvant. Moreover, activin C was found to inhibit the inflammation-induced phosphorylation of extracellular signal-regulated kinase in the dorsal root ganglia and the dorsal spinal cord. Thus, activin C functions as an endogenous suppressor of inflammatory nociceptive transmission and may have a therapeutic potential for treatment of inflammatory pain.
学科主题	Neurosciences & Neurology
类目[WOS]	Clinical Neurology ; Neurosciences
关键词[WOS]	DORSAL-ROOT GANGLION ; GENE-RELATED PEPTIDE ; BONE MORPHOGENETIC PROTEINS ; SPINAL SUBARACHNOID SPACE ; SIGNAL-REGULATED KINASE ; FOLLISTATIN-LIKE 1 ; NEUROPATHIC PAIN ; SENSORY NEURONS ; LIVER-REGENERATION ; BETA-C
收录类别	SCI
语种	英语
WOS记录号	WOS:000300485600015
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/708]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Liu, XJ,Zhang, FX,Liu, H,et al. Activin C expressed in nociceptive afferent neurons is required for suppressing inflammatory pain[J]. BRAIN,2012,135(1):391-403.
APA	Liu, XJ.,Zhang, FX.,Liu, H.,Li, KC.,Lu, YJ.,...&Zhang, X.(2012).Activin C expressed in nociceptive afferent neurons is required for suppressing inflammatory pain.BRAIN,135(1),391-403.
MLA	Liu, XJ,et al."Activin C expressed in nociceptive afferent neurons is required for suppressing inflammatory pain".BRAIN 135.1(2012):391-403.