The Essential Role of Mbd5 in the Regulation of Somatic Growth and Glucose Homeostasis in Mice

	The Essential Role of Mbd5 in the Regulation of Somatic Growth and Glucose Homeostasis in Mice
	Du, YR; Liu, B; Guo, F; Xu, GF; Ding, YQ; Liu, Y; Sun, X; Xu, GL
刊名	PLOS ONE
	2012
卷号	7 期号:10 页码:e47358-e47358
通讯作者	Xu, GL (reprint author), Chinese Acad Sci, State Key Lab Mol Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai, Peoples R China.,glxu@sibs.ac.cn
英文摘要	Methyl-CpG binding domain protein 5 (MBD5) belongs to the MBD family proteins, which play central roles in transcriptional regulation and development. The significance of MBD5 function is highlighted by recent studies implicating it as a candidate gene involved in human 2q23.1 microdeletion syndrome. To investigate the physiological role of Mbd5, we generated knockout mice. The Mbd5-deficient mice showed growth retardation, wasting and pre-weaning lethality. The observed growth retardation was associated with the impairment of GH/IGF-1 axis in Mbd5-null pups. Conditional knockout of Mbd5 in the brain resulted in the similar phenotypes as whole body deletion, indicating that Mbd5 functions in the nervous system to regulate postnatal growth. Moreover, the mutant mice also displayed enhanced glucose tolerance and elevated insulin sensitivity as a result of increased insulin signaling, ultimately resulting in disturbed glucose homeostasis and hypoglycemia. These results indicate Mbd5 as an essential factor for mouse postnatal growth and maintenance of glucose homeostasis.
学科主题	Science & Technology - Other Topics
类目[WOS]	Multidisciplinary Sciences
关键词[WOS]	CPG-BINDING DOMAIN ; DNA METHYLATION ; MENTAL-RETARDATION ; POSTNATAL-GROWTH ; NERVOUS-SYSTEM ; FACTOR I ; HORMONE ; GENE ; INSULIN ; TRANSCRIPTION
收录类别	SCI
语种	英语
WOS记录号	WOS:000309995100099
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/647]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Du, YR,Liu, B,Guo, F,et al. The Essential Role of Mbd5 in the Regulation of Somatic Growth and Glucose Homeostasis in Mice[J]. PLOS ONE,2012,7(10):e47358-e47358.
APA	Du, YR.,Liu, B.,Guo, F.,Xu, GF.,Ding, YQ.,...&Xu, GL.(2012).The Essential Role of Mbd5 in the Regulation of Somatic Growth and Glucose Homeostasis in Mice.PLOS ONE,7(10),e47358-e47358.
MLA	Du, YR,et al."The Essential Role of Mbd5 in the Regulation of Somatic Growth and Glucose Homeostasis in Mice".PLOS ONE 7.10(2012):e47358-e47358.