Interferon--armed oncolytic adenovirus induces both apoptosis and necroptosis in cancer cells

	Interferon--armed oncolytic adenovirus induces both apoptosis and necroptosis in cancer cells
	Huang, HL; Xiao, T; He, LF; Ji, HB; Liu, XY
刊名	ACTA BIOCHIMICA ET BIOPHYSICA SINICA
	2012
卷号	44 期号:9 页码:737-745
关键词	IFN- cell cycle arrest apoptosis necroptosis synergism
通讯作者	Ji, HB (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China.,hbji@sibs.ac.cn ; xyliu@sibs.ac.cn
英文摘要	Interferon- (IFN-) has been widely used in cancer therapy, but the clinical trial results are generally disappointing. Our previous studies have shown that an oncolytic adenovirus carrying IFN- (ZD55-IFN-) exhibits significant anti-tumor activities. However, the underlying mechanisms are not clear. Here we showed that ZD55-IFN- infection-induced S-phase cell cycle arrest in a p53-dependent manner by activating the ataxia telangiectasia mutated-dependent DNA damage pathway. In addition, ZD55-IFN- infection could initiate both caspase-dependent apoptosis and necroptosis in cancer cells. More importantly, ZD55-IFN- showed a synergistic effect on cancer cells when combined with doxorubicin. These results suggest that the combination of ZD55-IFN- with doxorubicin may represent a promising clinical strategy in cancer therapy.
学科主题	Biochemistry & Molecular Biology; Biophysics
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]	DRUG-RESISTANCE ; S-PHASE ; DEATH ; NECROSIS ; BETA ; MECHANISMS ; INDUCTION ; EXPRESSION ; ARREST ; CYCLE
收录类别	SCI
语种	英语
WOS记录号	WOS:000308010400003
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/640]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Huang, HL,Xiao, T,He, LF,et al. Interferon--armed oncolytic adenovirus induces both apoptosis and necroptosis in cancer cells[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2012,44(9):737-745.
APA	Huang, HL,Xiao, T,He, LF,Ji, HB,&Liu, XY.(2012).Interferon--armed oncolytic adenovirus induces both apoptosis and necroptosis in cancer cells.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,44(9),737-745.
MLA	Huang, HL,et al."Interferon--armed oncolytic adenovirus induces both apoptosis and necroptosis in cancer cells".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 44.9(2012):737-745.