NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens

	NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens
	Yao, Y; Wang, Y; Chen, F; Huang, Y; Zhu, S; Leng, Q; Wang, H; Shi, Y; Qian, Y
刊名	CELL RESEARCH
	2012
卷号	22 期号:5 页码:836-847
关键词	NLRC5 MHC class I infection inflammasome
通讯作者	Qian, Y (reprint author), Chinese Acad Sci, Shanghai Jiao Tong Univ, Sch Med,Key Lab Stem Cell Biol, Shanghai Inst Biol Sci,Inst Hlth Sci, Shanghai 200025, Peoples R China.,ycqian@sibs.ac.cn
英文摘要	NOD-like receptors (NLRs) are a family of intracellular proteins that play critical roles in innate immunity against microbial infection. NLRC5, the largest member of the NLR family, has recently attracted much attention. However, in vitro studies have reported inconsistent results about the roles of NLRC5 in host defense and in regulating immune signaling pathways. The in vivo function of NLRC5 remains unknown. Here, we report that NLRC5 is a critical regulator of host defense against intracellular pathogens in vivo. NLRC5 was specifically required for the expression of genes involved in MHC class I antigen presentation. NLRC5-deficient mice showed a profound defect in the expression of MHC class I genes and a concomitant failure to activate L. monocytogenes-specific CD8(+) T cell responses, including activation, proliferation and cytotoxicity, and the mutant mice were more susceptible to the pathogen infection. NLRP3-mediated inflammasome activation was also partially impaired in NLRC5-deficient mice. However, NLRC5 was dispensable for pathogen-induced expression of NF-kappa B-dependent pro-inflammatory genes as well as type I interferon genes. Thus, NLRC5 critically regulates MHC class I antigen presentation to control intracellular pathogen infection.
学科主题	Cell Biology
类目[WOS]	Cell Biology
关键词[WOS]	NUCLEOTIDE-BINDING DOMAIN ; FAMILY-MEMBER NLRC5 ; T-CELLS ; INFLAMMASOME ; CIITA ; RESPONSES ; PATHWAYS
收录类别	SCI
语种	英语
WOS记录号	WOS:000303611500008
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/596]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Yao, Y,Wang, Y,Chen, F,et al. NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens[J]. CELL RESEARCH,2012,22(5):836-847.
APA	Yao, Y.,Wang, Y.,Chen, F.,Huang, Y.,Zhu, S.,...&Qian, Y.(2012).NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens.CELL RESEARCH,22(5),836-847.
MLA	Yao, Y,et al."NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens".CELL RESEARCH 22.5(2012):836-847.