The regulation of integrin function by divalent cations

	The regulation of integrin function by divalent cations
	Zhang, K; Chen, JF
刊名	CELL ADHESION & MIGRATION
	2012
卷号	6 期号:1 页码:20-29
关键词	integrin divalent cations affinity MIDAS ADMIDAS SyMBS
通讯作者	Chen, JF (reprint author), Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, State Key Lab Cell Biol, Shanghai, Peoples R China.,jfchen@sibs.ac.cn
英文摘要	Integrins are a family of alpha/beta heterodimeric adhesion metallo-protein receptors and their functions are highly dependent on and regulated by different divalent cations. Recently advanced studies have revolutionized our perception of integrin metal ion-binding sites and their specific functions. Ligand binding to integrins is bridged by a divalent cation bound at the MIDAS motif on top of either alpha I domain in I domain-containing integrins or beta I domain in alpha I domain-less integrins. The MIDAS motif in beta I domain is flanked by ADMIDAS and SyMBS, the other two crucial metal ion binding sites playing pivotal roles in the regulation of integrin affinity and bidirectional signaling across the plasma membrane. The beta-propeller domain of alpha subunit contains three or four beta-hairpin loop-like Ca2+-binding motifs that have essential roles in integrin biogenesis. The function of another Ca2+-binding motif located at the genu of alpha subunit remains elusive. Here, we provide an overview of the integrin metal ion-binding sites and discuss their roles in the regulation of integrin functions.
学科主题	Cell Biology
类目[WOS]	Cell Biology
关键词[WOS]	PLATELET GLYCOPROTEIN-IIB ; CALCIUM-BINDING DOMAINS ; FUNCTION-ASSOCIATED ANTIGEN-1 ; SITE-DIRECTED MUTAGENESIS ; AMINO-ACID SUBSTITUTION ; METAL-ION BINDING ; I-LIKE DOMAIN ; LIGAND-BINDING ; CELL-ADHESION ; A-DOMAIN
收录类别	SCI
语种	英语
WOS记录号	WOS:000304611500005
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/532]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Zhang, K,Chen, JF. The regulation of integrin function by divalent cations[J]. CELL ADHESION & MIGRATION,2012,6(1):20-29.
APA	Zhang, K,&Chen, JF.(2012).The regulation of integrin function by divalent cations.CELL ADHESION & MIGRATION,6(1),20-29.
MLA	Zhang, K,et al."The regulation of integrin function by divalent cations".CELL ADHESION & MIGRATION 6.1(2012):20-29.