An Androgen Receptor-MicroRNA-29a Regulatory Circuitry in Mouse Epididymis

	An Androgen Receptor-MicroRNA-29a Regulatory Circuitry in Mouse Epididymis
	Ma, WB; Hu, SG; Yao, GX; Xie, SS; Ni, MJ; Liu, Q; Gao, XX; Zhang, J; Huang, XX; Zhang, YL
刊名	JOURNAL OF BIOLOGICAL CHEMISTRY
	2013
卷号	288 期号:41 页码:29369-29381
通讯作者	Huang, XX (reprint author), Nanjing Univ, Model Anim Res Ctr, Nanjing 210061, Jiangsu, Peoples R China.,xingxuhuang@mail.nju.edu.cn
英文摘要	MicroRNAs are involved in a number of cellular processes; thus, their deregulation is usually apt to the occurrence of diverse diseases. Previous studies indicate that abnormally up-regulated miR-29a is associated with several diseases, such as human acute myeloid leukemia and diabetes; therefore, the proper level of miR-29a is critical for homeostasis. Herein, we observed that miR-29a was repressed by androgen/androgen receptor signaling in mouse epididymis by targeting a conserved androgen response element located 8 kb upstream of miR-29b1a loci. It is well known that multiple regulatory programs often form a complicated network. Here, we found that miR-29a reversibly suppressed androgen receptor and its target genes by targeting IGF1 and p53 pathways. miR-29b1a-overexpressing transgenic mice displayed epididymis hypoplasia partially similar to the phenotype of those mice with an impaired androgen-androgen receptor signal system. Taken together, the results demonstrated that there is a regulatory circuitry between the androgen signaling pathway and miR-29a in mouse epididymis that may be vital for epididymal development and functions.
学科主题	Biochemistry & Molecular Biology
类目[WOS]	Biochemistry & Molecular Biology
关键词[WOS]	PROSTATE-CANCER CELLS ; RECEPTOR AR COREGULATORS ; RENAL FIBROSIS ; EXPRESSION ; MICRORNA ; DISEASE ; GROWTH ; MIR-29 ; LINES ; GENE
收录类别	SCI
语种	英语
WOS记录号	WOS:000330615300016
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/475]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Ma, WB,Hu, SG,Yao, GX,et al. An Androgen Receptor-MicroRNA-29a Regulatory Circuitry in Mouse Epididymis[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2013,288(41):29369-29381.
APA	Ma, WB.,Hu, SG.,Yao, GX.,Xie, SS.,Ni, MJ.,...&Zhang, YL.(2013).An Androgen Receptor-MicroRNA-29a Regulatory Circuitry in Mouse Epididymis.JOURNAL OF BIOLOGICAL CHEMISTRY,288(41),29369-29381.
MLA	Ma, WB,et al."An Androgen Receptor-MicroRNA-29a Regulatory Circuitry in Mouse Epididymis".JOURNAL OF BIOLOGICAL CHEMISTRY 288.41(2013):29369-29381.