A Low-Toxic Multifunctional Nanoplatform Based on Cu9S5@mSiO(2) Core-Shell Nanocomposites: Combining Photothermal- and Chemotherapies with Infrared Thermal Imaging for Cancer Treatment

	A Low-Toxic Multifunctional Nanoplatform Based on Cu9S5@mSiO(2) Core-Shell Nanocomposites: Combining Photothermal- and Chemotherapies with Infrared Thermal Imaging for Cancer Treatment
	Song, GS; Wang, QA; Wang, Y; Lv, G; Li, C; Zou, RJ; Chen, ZG; Qin, ZY; Huo, KK; Hu, RG
刊名	ADVANCED FUNCTIONAL MATERIALS
	2013
卷号	23 期号:35 页码:4281-4292
关键词	low-toxicity materials photothermal therapy chemotherapy infrared thermal imaging
通讯作者	Song, GS (reprint author), Donghua Univ, Coll Mat Sci & Engn, State Key Lab Modificat Chem Fibers & Polymer Mat, Shanghai 201620, Peoples R China.,hu.junqing@dhu.edu.cn
英文摘要	Copper chalcogenides have been demonstrated to be a promising photothermal agent due to their high photothermal conversion efficiency, synthetic simplicity, and low cost. However, the hydrophobic and less biocompatible characteristics associated with their synthetic processes hamper widely biological applications. An alternative strategy for improving hydrophilicity and biocompatibility is to coat the copper chalcogenide nanomaterials with silica shell. Herein, the rational preparation design results in successful coating mesoporous silica (mSiO(2)) on as-synthesized Cu9S5 nanocrystals, forming Cu9S5@mSiO(2)-PEG core-shell nanostructures. As-prepared Cu9S5@mSiO(2)-PEG core-shell nanostructures show low cytotoxicity and excellent blood compatibility, and are effectively employed for photothermal ablation of cancer cells and infrared thermal imaging. Moreover, anticancer drug of doxorubicin (DOX)-loaded Cu9S5@mSiO(2)-PEG core-shell nanostructures show pH sensitive release profile and are therefore beneficial to delivery of DOX into cancer cells for chemotherapy. Importantly, the combination of photothermal- and chemotherapies demonstrates better effects of therapy on cancer treatment than individual therapy approaches in vitro and in vivo.
学科主题	Chemistry; Science & Technology - Other Topics; Materials Science; Physics
类目[WOS]	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
关键词[WOS]	MESOPOROUS SILICA NANOPARTICLES ; REDUCED GRAPHENE OXIDE ; DRUG-DELIVERY ; QUANTUM DOTS ; IN-VIVO ; ORGANIC NANOPARTICLES ; CARBON NANOTUBES ; GOLD NANOSPHERES ; FACILE SYNTHESIS ; THERAPY
收录类别	SCI
语种	英语
WOS记录号	WOS:000327492800004
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/474]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Song, GS,Wang, QA,Wang, Y,et al. A Low-Toxic Multifunctional Nanoplatform Based on Cu9S5@mSiO(2) Core-Shell Nanocomposites: Combining Photothermal- and Chemotherapies with Infrared Thermal Imaging for Cancer Treatment[J]. ADVANCED FUNCTIONAL MATERIALS,2013,23(35):4281-4292.
APA	Song, GS.,Wang, QA.,Wang, Y.,Lv, G.,Li, C.,...&Hu, JQ.(2013).A Low-Toxic Multifunctional Nanoplatform Based on Cu9S5@mSiO(2) Core-Shell Nanocomposites: Combining Photothermal- and Chemotherapies with Infrared Thermal Imaging for Cancer Treatment.ADVANCED FUNCTIONAL MATERIALS,23(35),4281-4292.
MLA	Song, GS,et al."A Low-Toxic Multifunctional Nanoplatform Based on Cu9S5@mSiO(2) Core-Shell Nanocomposites: Combining Photothermal- and Chemotherapies with Infrared Thermal Imaging for Cancer Treatment".ADVANCED FUNCTIONAL MATERIALS 23.35(2013):4281-4292.