Viral and Host Factors Required for Avian H5N1 Influenza A Virus Replication in Mammalian Cells

	Viral and Host Factors Required for Avian H5N1 Influenza A Virus Replication in Mammalian Cells
	Zhang, H; Hale, BG; Xu, K; Sun, B
刊名	VIRUSES-BASEL
	2013
卷号	5 期号:6 页码:1431-1446
关键词	avian H5N1 influenza A viruses replication in mammalian cells molecular mechanisms adaptive mutation species barrier
通讯作者	Sun, B (reprint author), Chinese Acad Sci, Mol Virus Unit, Key Lab Mol Virol & Immunol, Inst Pasteur Shanghai,Shanghai Inst Biol Sci, 225 South Chongqing Rd, Shanghai 200025, Peoples R China.,zhanghong@sibs.ac.cn ; ben.hale@glasgow.ac.uk ; kxu@sibs.ac.cn ; bsun@sibs.ac.cn
英文摘要	Following the initial and sporadic emergence into humans of highly pathogenic avian H5N1 influenza A viruses in Hong Kong in 1997, we have come to realize the potential for avian influenza A viruses to be transmitted directly from birds to humans. Understanding the basic viral and cellular mechanisms that contribute to infection of mammalian species with avian influenza viruses is essential for developing prevention and control measures against possible future human pandemics. Multiple physical and functional cellular barriers can restrict influenza A virus infection in a new host species, including the cell membrane, the nuclear envelope, the nuclear environment, and innate antiviral responses. In this review, we summarize current knowledge on viral and host factors required for avian H5N1 influenza A viruses to successfully establish infections in mammalian cells. We focus on the molecular mechanisms underpinning mammalian host restrictions, as well as the adaptive mutations that are necessary for an avian influenza virus to overcome them. It is likely that many more viral and host determinants remain to be discovered, and future research in this area should provide novel and translational insights into the biology of influenza virus-host interactions.
学科主题	Virology
类目[WOS]	Virology
关键词[WOS]	NUCLEAR-LOCALIZATION SEQUENCES ; SINGLE AMINO-ACID ; RECEPTOR-BINDING SPECIFICITY ; HUMAN AIRWAY EPITHELIUM ; RNA-POLYMERASE COMPLEX ; NS1 PROTEIN ; RIBONUCLEOPROTEIN COMPLEXES ; SUBSTRATE-SPECIFICITY ; BRITISH-COLUMBIA ; HUMAN ILLNESS
收录类别	SCI
语种	英语
WOS记录号	WOS:000320769900004
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/407]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Zhang, H,Hale, BG,Xu, K,et al. Viral and Host Factors Required for Avian H5N1 Influenza A Virus Replication in Mammalian Cells[J]. VIRUSES-BASEL,2013,5(6):1431-1446.
APA	Zhang, H,Hale, BG,Xu, K,&Sun, B.(2013).Viral and Host Factors Required for Avian H5N1 Influenza A Virus Replication in Mammalian Cells.VIRUSES-BASEL,5(6),1431-1446.
MLA	Zhang, H,et al."Viral and Host Factors Required for Avian H5N1 Influenza A Virus Replication in Mammalian Cells".VIRUSES-BASEL 5.6(2013):1431-1446.