Ter94 ATPase Complex Targets K11-Linked Ubiquitinated Ci to Proteasomes for Partial Degradation

	Ter94 ATPase Complex Targets K11-Linked Ubiquitinated Ci to Proteasomes for Partial Degradation
	Zhang, Z; Lv, XD; Yin, WC; Zhang, XY; Feng, J; Wu, WQ; Hui, CC; Zhang, L; Zhao, Y
刊名	DEVELOPMENTAL CELL
	2013
卷号	25 期号:6 页码:636-644
通讯作者	Zhang, L (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China.,rayzhang@sibcb.ac.cn ; yunzhao@sibcb.ac.cn
英文摘要	The Cubitus interruptus (Ci)/Gli family of transcription factors can be degraded either completely or partially from a full-length form (Ci155/Gli(FL)) to a truncated repressor (Ci75/Gli(R)) by proteasomes to mediate Hedgehog (Hh) signaling. The mechanism by which proteasomes distinguish ubiquitinated Ci/Gli to carry out complete versus partial degradation is not known. Here, we show that Ter94 ATPase and its mammalian counterpart, p97, are involved in processing Ci and Gli3 into Ci75 and Gli3(R), respectively. Ter94 regulates the partial degradation of ubiquitinated Ci by Cul1-Slimb-based E3 ligase through its adaptors Ufd1-like and dNpl4. We demonstrate that Cul1-Slimb-based E3 ligase, but not Cul3-Rdx-based E3 ligase, modifies Ci by efficient addition of K11-linked ubiquitin chains. Ter94(Ufd1-like/dNpl4) complex interacts directly with Cul1-Slimb, and, intriguingly, it prefers K11-linked ubiquitinated Ci. Thus, Ter94 ATPase and K11-linked ubiquitination in Ci contribute to the selectivity by proteasomes for partial degradation.
学科主题	Cell Biology; Developmental Biology
类目[WOS]	Cell Biology ; Developmental Biology
关键词[WOS]	CUBITUS-INTERRUPTUS PROTEIN ; NF-KAPPA-B ; TRANSCRIPTION FACTOR ; AAA-ATPASE ; MEMBRANE-FUSION ; HEDGEHOG ; DROSOPHILA ; REPRESSOR ; PATHWAY ; LIGASES
收录类别	SCI
语种	英语
WOS记录号	WOS:000321483000011
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/405]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Zhang, Z,Lv, XD,Yin, WC,et al. Ter94 ATPase Complex Targets K11-Linked Ubiquitinated Ci to Proteasomes for Partial Degradation[J]. DEVELOPMENTAL CELL,2013,25(6):636-644.
APA	Zhang, Z.,Lv, XD.,Yin, WC.,Zhang, XY.,Feng, J.,...&Zhao, Y.(2013).Ter94 ATPase Complex Targets K11-Linked Ubiquitinated Ci to Proteasomes for Partial Degradation.DEVELOPMENTAL CELL,25(6),636-644.
MLA	Zhang, Z,et al."Ter94 ATPase Complex Targets K11-Linked Ubiquitinated Ci to Proteasomes for Partial Degradation".DEVELOPMENTAL CELL 25.6(2013):636-644.