Negative Regulation of Nmi on Virus-Triggered Type I IFN Production by Targeting IRF7

	Negative Regulation of Nmi on Virus-Triggered Type I IFN Production by Targeting IRF7
	Wang, J; Yang, B; Hu, Y; Zheng, YH; Zhou, HY; Wang, YM; Ma, YL; Mao, KR; Yang, LL; Lin, GM
刊名	JOURNAL OF IMMUNOLOGY
	2013
卷号	191 期号:6 页码:3393-3399
通讯作者	Sun, B (reprint author), Chinese Acad Sci, State Key Lab Cell Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,wxd@sibs.ac.cn ; bsun@sibs.ac.cn
英文摘要	Viral infection causes host cells to produce type I IFNs, which play a critical role in viral clearance. IFN regulatory factor (IRF) 7 is the master regulator of type I IFN-dependent immune responses. In this article, we report that N-Myc and STATs interactor (Nmi), a Sendai virus-inducible protein, interacted with IRF7 and inhibited virus-triggered type I IFN production. The overexpression of Nmi inhibited the Sendai virus-triggered induction of type I IFNs, whereas the knockdown of Nmi promoted IFN production. Furthermore, the enhanced production of IFNs resulting from Nmi knockdown was sufficient to protect cells from infection by vesicular stomatitis virus. In addition, Nmi was found to promote the K48-linked ubiquitination of IRF7 and the proteasome-dependent degradation of this protein. Finally, an impairment of antiviral responses is also detectable in Nmi-transgenic mice. These findings suggest that Nmi is a negative regulator of the virus-triggered induction of type I IFNs that targets IRF7.
学科主题	Immunology
类目[WOS]	Immunology
关键词[WOS]	INTERACTING PROTEIN NMI ; NF-KAPPA-B ; ANTIVIRAL RESPONSE ; TRANSCRIPTION FACTOR ; ADAPTER PROTEIN ; INTERFERON ; MYC ; PATHWAY ; IFP35 ; TRAF3
收录类别	SCI
语种	英语
WOS记录号	WOS:000324206900057
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/404]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Wang, J,Yang, B,Hu, Y,et al. Negative Regulation of Nmi on Virus-Triggered Type I IFN Production by Targeting IRF7[J]. JOURNAL OF IMMUNOLOGY,2013,191(6):3393-3399.
APA	Wang, J.,Yang, B.,Hu, Y.,Zheng, YH.,Zhou, HY.,...&Sun, B.(2013).Negative Regulation of Nmi on Virus-Triggered Type I IFN Production by Targeting IRF7.JOURNAL OF IMMUNOLOGY,191(6),3393-3399.
MLA	Wang, J,et al."Negative Regulation of Nmi on Virus-Triggered Type I IFN Production by Targeting IRF7".JOURNAL OF IMMUNOLOGY 191.6(2013):3393-3399.