Negative regulation of NLRP3 inflammasome signaling

	Negative regulation of NLRP3 inflammasome signaling
	Chen, SZ; Sun, B
刊名	PROTEIN & CELL
	2013
卷号	4 期号:4 页码:251-258
关键词	inflammasome NLRP3 negative regulation inflammation
通讯作者	Sun, B (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Cell Biol, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China.,bsun@sibs.ac.cn
英文摘要	Inflammasomes are multiprotein complexes that serve as a platform for caspase-1 activation and interleukin-1 beta (IL-1 beta) maturation as well as pyroptosis. Though a number of inflammasomes have been described, the NLRP3 inflammasome is the most extensively studied. NLRP3 inflammasome is triggered by a variety of stimuli, including infection, tissue damage and metabolic dysregulation, and then activated through an integrated cellular signal. Many regulatory mechanisms have been identified to attenuate NLRP3 inflammasome signaling at multiple steps. Here, we review the developments in the negative regulation of NLRP3 inflammasome that protect host from inflammatory damage.
学科主题	Cell Biology
类目[WOS]	Cell Biology
关键词[WOS]	COLD AUTOINFLAMMATORY SYNDROME ; ADAPTIVE IMMUNE-RESPONSES ; NITRIC-OXIDE ; NALP3 INFLAMMASOME ; IL-1-BETA PRODUCTION ; INTERLEUKIN-1-BETA GENERATION ; CYTOPLASMIC DNA ; DOMAIN PROTEIN ; URIC-ACID ; ACTIVATION
收录类别	SCI
语种	英语
WOS记录号	WOS:000317018000003
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/381]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Chen, SZ,Sun, B. Negative regulation of NLRP3 inflammasome signaling[J]. PROTEIN & CELL,2013,4(4):251-258.
APA	Chen, SZ,&Sun, B.(2013).Negative regulation of NLRP3 inflammasome signaling.PROTEIN & CELL,4(4),251-258.
MLA	Chen, SZ,et al."Negative regulation of NLRP3 inflammasome signaling".PROTEIN & CELL 4.4(2013):251-258.