Drosophila Ste-20 Family Protein Kinase, Hippo, Modulates Fat Cell Proliferation

	Drosophila Ste-20 Family Protein Kinase, Hippo, Modulates Fat Cell Proliferation
	Huang, HL; Wu, WQ; Zhang, L; Liu, XY
刊名	PLOS ONE
	2013
卷号	8 期号:4 页码:e61740-e61740
通讯作者	Zhang, L (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai, Peoples R China.,rayzhang@sibs.ac.cn ; xyliu@sibs.ac.cn
英文摘要	Background: Evolutionarily conserved Hippo (Hpo) pathway plays a pivotal role in the control of organ size. Although the Hpo pathway regulates proliferation of a variety of epidermal cells, its function in non-ectoderm-derived cells is largely unknown. Methodology/Principal Findings: Through methods including fat quantification assays, starvation assays, in vivo labeling assays, we show that overexpression of Hpo in Drosophila melanogaster fat body restricts Drosophila body growth and reduces fat storage through regulation of adipocyte proliferation rather than through influencing the size of fat cells and lipid metabolism, whereas compromising Hpo activity results in weight gain and greater fat storage. Furthermore, we provide evidence that Yorkie (Yki, a transcriptional coactivator that functions in the Hpo pathway) antagonizes Hpo to modulate fat storage in Drosophila. Conclusions/Significance: Our findings specify a role of Hpo in controlling mesoderm-derived cell proliferation. The observed anti-obesity effects of Hpo may indicate great potential for its utilization in anti-obesity therapeutics.
学科主题	Science & Technology - Other Topics
类目[WOS]	Multidisciplinary Sciences
关键词[WOS]	ORGAN SIZE CONTROL ; TUMOR-SUPPRESSOR ; PROMOTES APOPTOSIS ; CURRENT STRATEGIES ; ANTIOBESITY DRUGS ; SIGNALING PATHWAY ; TEAD/TEF FAMILY ; OBESITY ; GROWTH ; ENCODES
收录类别	SCI
语种	英语
WOS记录号	WOS:000317908700057
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/365]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Huang, HL,Wu, WQ,Zhang, L,et al. Drosophila Ste-20 Family Protein Kinase, Hippo, Modulates Fat Cell Proliferation[J]. PLOS ONE,2013,8(4):e61740-e61740.
APA	Huang, HL,Wu, WQ,Zhang, L,&Liu, XY.(2013).Drosophila Ste-20 Family Protein Kinase, Hippo, Modulates Fat Cell Proliferation.PLOS ONE,8(4),e61740-e61740.
MLA	Huang, HL,et al."Drosophila Ste-20 Family Protein Kinase, Hippo, Modulates Fat Cell Proliferation".PLOS ONE 8.4(2013):e61740-e61740.