Tet1 is required for Rb phosphorylation during G1/S phase transition

	Tet1 is required for Rb phosphorylation during G1/S phase transition
	Huang, SS; Zhu, ZQ; Wang, YQ; Wang, YR; Xu, LX; Chen, XM; Xu, Q; Zhang, QM; Zhao, X; Yu, Y
刊名	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
	2013
卷号	434 期号:2 页码:241-244
关键词	Tet1 Hydroxylase Rb phosphorylation Cyclin D1 G1/S phase entry
通讯作者	Wu, DL (reprint author), Tongji Hosp, Dept Urol, 389 Xincun Rd, Shanghai 200065, Peoples R China.,yuyi@sibcb.ac.cn ; wudenglong@163.com
英文摘要	DNA methylation plays an important role in many biological processes, including regulation of gene expression, maintenance of chromatin conformation and genomic stability. TET-family proteins convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), which indicates that these enzymes may participate in DNA demethylation. The function of TET1 has not yet been well characterized in somatic cells. Here, we show that depletion of Tet1 in NIH3T3 cells inhibits cell growth. Furthermore, Tet1 knockdown blocks cyclin D1 accumulation in G1 phase, inhibits Rb phosphorylation and consequently delays entrance to G1/S phase. Taken together, this study demonstrates that Tet1 is required for cell proliferation and that this process is mediated through the Rb pathway. (c) 2013 Elsevier Inc. All rights reserved.
学科主题	Biochemistry & Molecular Biology; Biophysics
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]	ACUTE MYELOID-LEUKEMIA ; ACTIVE DNA DEMETHYLATION ; EMBRYONIC STEM-CELLS ; CANCER ; EPIGENETICS ; MUTATIONS ; METHYLATION ; MLL ; 5-HYDROXYMETHYLCYTOSINE ; T(10/11)(Q22,Q23)
收录类别	SCI
语种	英语
WOS记录号	WOS:000319098800010
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/336]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Huang, SS,Zhu, ZQ,Wang, YQ,et al. Tet1 is required for Rb phosphorylation during G1/S phase transition[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2013,434(2):241-244.
APA	Huang, SS.,Zhu, ZQ.,Wang, YQ.,Wang, YR.,Xu, LX.,...&Wu, DL.(2013).Tet1 is required for Rb phosphorylation during G1/S phase transition.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,434(2),241-244.
MLA	Huang, SS,et al."Tet1 is required for Rb phosphorylation during G1/S phase transition".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 434.2(2013):241-244.