Tet1 Regulates Adult Hippocampal Neurogenesis and Cognition

	Tet1 Regulates Adult Hippocampal Neurogenesis and Cognition
	Zhang, RR; Cui, QY; Murai, K; Lim, YC; Smith, ZD; Jin, SN; Ye, P; Rosa, L; Lee, YK; Wu, HP
刊名	CELL STEM CELL
	2013
卷号	13 期号:2 页码:237-245
通讯作者	Ding, CM (reprint author), Agcy Sci Technol & Res, Singapore Inst Clin Sci, Singapore 117609, Singapore.,ding_chunming@sics.a-star.edu.sg ; yshi@coh.org ; glxu@sibs.ac.cn
英文摘要	DNA hydroxylation catalyzed by Tet dioxygenases occurs abundantly in embryonic stem cells and neurons in mammals. However, its biological function in vivo is largely unknown. Here, we demonstrate that Tet1 plays an important role in regulating neural progenitor cell proliferation in adult mouse brain. Mice lacking Tet1 exhibit impaired hippocampal neurogenesis accompanied by poor learning and memory. In adult neural progenitor cells deficient in Tet1, a cohort of genes involved in progenitor proliferation were hypermethylated and downregulated. Our results indicate that Tet1 is positively involved in the epigenetic regulation of neural progenitor cell proliferation in the adult brain.
学科主题	Cell Biology
类目[WOS]	Cell & Tissue Engineering ; Cell Biology
关键词[WOS]	ACTIVE DNA DEMETHYLATION ; EMBRYONIC STEM-CELLS ; POSTNATAL-DEVELOPMENT ; GENE-EXPRESSION ; MAMMALIAN DNA ; NEURAL STEM ; 5-HYDROXYMETHYLCYTOSINE ; BRAIN ; NEURONS ; 5-METHYLCYTOSINE
收录类别	SCI
语种	英语
WOS记录号	WOS:000329570600016
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/330]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Zhang, RR,Cui, QY,Murai, K,et al. Tet1 Regulates Adult Hippocampal Neurogenesis and Cognition[J]. CELL STEM CELL,2013,13(2):237-245.
APA	Zhang, RR.,Cui, QY.,Murai, K.,Lim, YC.,Smith, ZD.,...&Xu, GL.(2013).Tet1 Regulates Adult Hippocampal Neurogenesis and Cognition.CELL STEM CELL,13(2),237-245.
MLA	Zhang, RR,et al."Tet1 Regulates Adult Hippocampal Neurogenesis and Cognition".CELL STEM CELL 13.2(2013):237-245.