Th1/Th2 Cell's Function in Immune System

	Th1/Th2 Cell's Function in Immune System
	Zhang, Y; Zhang, YG; Gu, WP; He, L; Sun, B
刊名	T HELPER CELL DIFFERENTIATION AND THEIR FUNCTION
	2014
卷号	841 期号:1 页码:45-65
关键词	Th1/Th2 Animal model Genetic mutation
通讯作者	Sun, B (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Cell Biol, Inst Biochem & Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,bsun@sibs.ac.cn
英文摘要	CD4+ T helper cells regulate appropriate cellular and humoral immune responses to a wide range of pathogens and get involved in many diseases progress. The balance of the earliest determined CD4+ T helper cell subsets, Th1 and Th2, play an important role in allergy and autoimmune diseases. During the research, Animal models in immunology research are necessary and always the powerful tools for the basic scientific research. With the new sequence technologies, the finding of key gene mutation in Th1/Th2 cells has been proved to be related to human diseases. Here, we review four animal models about four key genes in Th1/Th2 cells to introduce the balance between Th1/Th2 cells. Furthermore, the related genetic mutations in human diseases and the new therapies are reviewed in this chapter, which show the importance of Th1/Th2 cells in human diseases further.
学科主题	Cell Biology; Immunology
类目[WOS]	Cell Biology ; Immunology
关键词[WOS]	CHRONIC MUCOCUTANEOUS CANDIDIASIS ; TRANSCRIPTION FACTOR GATA-3 ; DYSPLASIA HDR SYNDROME ; GENITAL-TRACT MALFORMATIONS ; FUNCTION STAT1 MUTATIONS ; DNA-BINDING PROTEIN ; C-MAF CONTROLS ; CD4 T-CELLS ; LUPUS-ERYTHEMATOSUS ; INBORN-ERRORS
收录类别	SCI
语种	英语
WOS记录号	WOS:000350419100004
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/307]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Zhang, Y,Zhang, YG,Gu, WP,et al. Th1/Th2 Cell's Function in Immune System[J]. T HELPER CELL DIFFERENTIATION AND THEIR FUNCTION,2014,841(1):45-65.
APA	Zhang, Y,Zhang, YG,Gu, WP,He, L,&Sun, B.(2014).Th1/Th2 Cell's Function in Immune System.T HELPER CELL DIFFERENTIATION AND THEIR FUNCTION,841(1),45-65.
MLA	Zhang, Y,et al."Th1/Th2 Cell's Function in Immune System".T HELPER CELL DIFFERENTIATION AND THEIR FUNCTION 841.1(2014):45-65.