Th1/Th2 Cell Differentiation and Molecular Signals

	Th1/Th2 Cell Differentiation and Molecular Signals
	Zhang, Y; Zhang, YG; Gu, WP; Sun, B
刊名	T HELPER CELL DIFFERENTIATION AND THEIR FUNCTION
	2014
卷号	841 期号:1 页码:15-44
关键词	Th1/Th2 Transcription factor Migration Epigenetics MicroRNA LnRNA
通讯作者	Sun, B (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,bsun@sibs.ac.cn
英文摘要	The distinctive differentiated states of the CD4+ T helper cells are determined by the set of transcription factors and the genes transcribed by the transcription factors. In vitro induction models, the major determinants of the cytokines present during the T-cell receptor (TCR)-mediated activation process. IL-12 and IFN-gamma make Naive CD4+ T cells highly express T-bet and STAT4 and differentiate to TH1 cells, while IL-4 make Naive CD4+ T cells highly express STAT6 and GATA3 and differentiated to TH2 cells. Even through T-bet and GATA3 are master regulators for TH1/TH2 cells differentiation. There are many other transcription factors, such as RUNX family proteins, IRF4, Dec2, Gfi1, Hlx, and JunB that can impair TH1/TH2 cells differentiation. In recent years, noncoding RNAs (microRNA and long non-coding RNA) join in the crowd. The leukocytes should migrate to the right place to show their impact. There are some successful strategies, which are revealed to targeting chemokines and their receptors, that have been developed to treat human immune-related diseases.
学科主题	Cell Biology; Immunology
类目[WOS]	Cell Biology ; Immunology
关键词[WOS]	CD4(+) T-CELLS ; CHEMOKINE RECEPTOR EXPRESSION ; LONG NONCODING RNAS ; CLASS-SWITCH RECOMBINATION ; PROTEIN-COUPLED RECEPTOR ; LOOP-HELIX PROTEINS ; DRY EYE SYNDROME ; TRANSCRIPTION-FACTOR ; FUNCTIONAL EXPRESSION ; CUTTING EDGE
收录类别	SCI
语种	英语
WOS记录号	WOS:000350419100003
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/306]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Zhang, Y,Zhang, YG,Gu, WP,et al. Th1/Th2 Cell Differentiation and Molecular Signals[J]. T HELPER CELL DIFFERENTIATION AND THEIR FUNCTION,2014,841(1):15-44.
APA	Zhang, Y,Zhang, YG,Gu, WP,&Sun, B.(2014).Th1/Th2 Cell Differentiation and Molecular Signals.T HELPER CELL DIFFERENTIATION AND THEIR FUNCTION,841(1),15-44.
MLA	Zhang, Y,et al."Th1/Th2 Cell Differentiation and Molecular Signals".T HELPER CELL DIFFERENTIATION AND THEIR FUNCTION 841.1(2014):15-44.