The mediator subunit Med23 contributes to controlling T-cell activation and prevents autoimmunity

	The mediator subunit Med23 contributes to controlling T-cell activation and prevents autoimmunity
	Sun, Y; Zhu, XY; Chen, XF; Liu, HF; Xu, Y; Chu, YJ; Wang, G; Liu, XL
刊名	NATURE COMMUNICATIONS
	2014
卷号	5 期号:1 页码:5225-5225
通讯作者	Wang, G (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China.,gwang@sibcb.ac.cn
英文摘要	T-cell activation is critical for successful immune responses and is controlled at multiple levels. Although many changes of T-cell receptor-associated signalling molecules affect T-cell activation, the transcriptional mechanisms that control this process remain largely unknown. Here we find that T cell-specific deletion of the mediator subunit Med23 leads to hyperactivation of T cells and aged Med23-deficient mice exhibit an autoimmune syndrome. Med23 specifically and consistently promotes the transcription of multiple negative regulators of T-cell activation. In the absence of Med23, the T-cell activation threshold is lower, which results in enhanced antitumour T-cell function. Cumulatively, our data suggest that Med23 contributes to controlling T-cell activation at the transcriptional level and prevents the development of autoimmunity.
学科主题	Science & Technology - Other Topics
类目[WOS]	Multidisciplinary Sciences
关键词[WOS]	TRANSCRIPTIONAL REGULATION ; COACTIVATOR COMPLEX ; POSITIVE SELECTION ; CBL-B ; THRESHOLDS ; EXPRESSION ; RECEPTOR ; QUIESCENCE ; TOLERANCE ; PATHWAY
收录类别	SCI
语种	英语
WOS记录号	WOS:000343983400002
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/285]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Sun, Y,Zhu, XY,Chen, XF,et al. The mediator subunit Med23 contributes to controlling T-cell activation and prevents autoimmunity[J]. NATURE COMMUNICATIONS,2014,5(1):5225-5225.
APA	Sun, Y.,Zhu, XY.,Chen, XF.,Liu, HF.,Xu, Y.,...&Liu, XL.(2014).The mediator subunit Med23 contributes to controlling T-cell activation and prevents autoimmunity.NATURE COMMUNICATIONS,5(1),5225-5225.
MLA	Sun, Y,et al."The mediator subunit Med23 contributes to controlling T-cell activation and prevents autoimmunity".NATURE COMMUNICATIONS 5.1(2014):5225-5225.