The Kto-Skd Complex Can Regulate ptc Expression by Interacting with Cubitus interruptus (Ci) in the Hedgehog Signaling Pathway

	The Kto-Skd Complex Can Regulate ptc Expression by Interacting with Cubitus interruptus (Ci) in the Hedgehog Signaling Pathway
	Mao, FF; Yang, XF; Fu, L; Lv, XD; Zhang, Z; Wu, WQ; Yang, SQ; Zhou, ZC; Zhang, L; Zhao, Y
刊名	JOURNAL OF BIOLOGICAL CHEMISTRY
	2014
卷号	289 期号:32 页码:22333-22341
通讯作者	Zhao, Y (reprint author), 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,yunzhao@sibcb.ac.cn
英文摘要	The hedgehog (Hh) signaling pathway plays a very important role in metazoan development by controlling pattern formation. Drosophila imaginal discs are subdivided into anterior and posterior compartments that derive from adjacent cell populations. The anterior/posterior (A/P) boundaries, which are critical to maintaining the position of organizers, are established by a complex mechanism involving Hh signaling. Here, we uncover the regulation of ptc in the Hh signaling pathway by two subunits of mediator complex, Kto and Skd, which can also regulate boundary location. Collectively, we provide further evidence that Kto-Skd affects the A/P-axial development of the whole wing disc. Kto can interact with Cubitus interruptus (Ci), bind to the Ci-binding region on ptc promoter, which are both regulated by Hh signals to down-regulate ptc expression.
学科主题	Biochemistry & Molecular Biology
类目[WOS]	Biochemistry & Molecular Biology
关键词[WOS]	MAMMALIAN MEDIATOR COMPLEX ; TRANSCRIPTIONAL ACTIVATION ; TARGET GENES ; COMPARTMENT BOUNDARIES ; DROSOPHILA ; PROTEIN ; SUBUNITS ; REPRESSOR ; YEAST ; BINDING
收录类别	SCI
语种	英语
WOS记录号	WOS:000340593500044
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/268]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Mao, FF,Yang, XF,Fu, L,et al. The Kto-Skd Complex Can Regulate ptc Expression by Interacting with Cubitus interruptus (Ci) in the Hedgehog Signaling Pathway[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2014,289(32):22333-22341.
APA	Mao, FF.,Yang, XF.,Fu, L.,Lv, XD.,Zhang, Z.,...&Zhao, Y.(2014).The Kto-Skd Complex Can Regulate ptc Expression by Interacting with Cubitus interruptus (Ci) in the Hedgehog Signaling Pathway.JOURNAL OF BIOLOGICAL CHEMISTRY,289(32),22333-22341.
MLA	Mao, FF,et al."The Kto-Skd Complex Can Regulate ptc Expression by Interacting with Cubitus interruptus (Ci) in the Hedgehog Signaling Pathway".JOURNAL OF BIOLOGICAL CHEMISTRY 289.32(2014):22333-22341.