A new kind of cell suicide: mechanisms and functions of programmed necrosis

	A new kind of cell suicide: mechanisms and functions of programmed necrosis
	Sun, LM; Wang, XD
刊名	TRENDS IN BIOCHEMICAL SCIENCES
	2014
卷号	39 期号:12 页码:587-593
关键词	programmed necrosis pseudokinase mixed lineage kinase domain-like protein (MLKL) necroptosis necrosis inhibitors necrosis biomarker
通讯作者	Sun, LM (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China.,liming.sun@sibcb.ac.cn
英文摘要	Classically, there are two major forms of cell death: necrosis, an unregulated digestion of cellular components; and apoptosis, a programmed mechanism that is promoted by caspases. However, another form of cell death has recently been identified that is inhibited by caspases, and yet occurs through a regulated mechanism, termed programmed necrosis or necroptosis. The biochemical basis of this program has begun to emerge, with the discovery of the receptor-interacting kinase RIP3 and its substrate, the pseudokinase mixed lineage kinase domain-like protein (MLKL), as core components. Furthermore, animal models have revealed significant functions for RIP3/MLKL-mediated necrotic cell death in immune responses against microbial infection and in the etiology of diseases involving tissue damage. This review discusses recent advances in our understanding of the mechanistic details and physiological functions of programmed necrosis.
学科主题	Biochemistry & Molecular Biology
类目[WOS]	Biochemistry & Molecular Biology
关键词[WOS]	MIXED LINEAGE KINASE ; DOMAIN-LIKE PROTEIN ; NF-KAPPA-B ; ALPHA-DEPENDENT APOPTOSIS ; TNF-ALPHA ; MEDIATES NECROPTOSIS ; SIGNALING COMPLEX ; DEATH PATHWAYS ; RIP1 KINASE ; RECEPTOR
收录类别	SCI
语种	英语
WOS记录号	WOS:000346233300004
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/248]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Sun, LM,Wang, XD. A new kind of cell suicide: mechanisms and functions of programmed necrosis[J]. TRENDS IN BIOCHEMICAL SCIENCES,2014,39(12):587-593.
APA	Sun, LM,&Wang, XD.(2014).A new kind of cell suicide: mechanisms and functions of programmed necrosis.TRENDS IN BIOCHEMICAL SCIENCES,39(12),587-593.
MLA	Sun, LM,et al."A new kind of cell suicide: mechanisms and functions of programmed necrosis".TRENDS IN BIOCHEMICAL SCIENCES 39.12(2014):587-593.