Smart Soup, a Traditional Chinese Medicine Formula, Ameliorates Amyloid Pathology and Related Cognitive Deficits

	Smart Soup, a Traditional Chinese Medicine Formula, Ameliorates Amyloid Pathology and Related Cognitive Deficits
	Hou, YJ; Wang, Y; Zhao, J; Li, XH; Cui, J; Ding, JQ; Wang, Y; Zeng, XL; Ling, Y; Shen, XH
刊名	PLOS ONE
	2014
卷号	9 期号:11 页码:e111215-e111215
通讯作者	Zhao, J (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Grad Sch, State Key Lab Cell Biol,Inst Biochem & Cell Biol, Shanghai, Peoples R China.,jzhao@sibs.ac.cn ; gpei@sibs.ac.cn
英文摘要	Alzheimer's disease (AD) is a progressive neurodegenerative disease that causes substantial public health care burdens. Intensive efforts have been made to find effective and safe disease-modifying treatment and symptomatic intervention alternatives against AD. Smart Soup (SS), a Chinese medicine formula composed of Rhizoma Acori Tatarinowii (AT), Poria cum Radix Pini (PRP) and Radix Polygalae (RP), is a typical prescription against memory deficits. Here, we assessed the efficacy of SS against AD. Oral administration of SS ameliorated the cognitive impairment of AD transgenic mice, with reduced A beta levels, retarded A beta amyloidosis and reduced A beta-induced gliosis and neuronal loss in the brains of AD mice. Consistently, SS treatment reduced amyloid-related locomotor dysfunctions and premature death of AD transgenic Drosophila. Mechanistic studies showed that RP reduced A beta generation, whereas AT and PRP exerted neuroprotective effects against A beta. Taken together, our study indicates that SS could be effective against AD, providing a practical therapeutic strategy against the disease.
学科主题	Science & Technology - Other Topics
类目[WOS]	Multidisciplinary Sciences
关键词[WOS]	ALZHEIMERS-DISEASE ; MOUSE MODEL ; MEMORY DEFICITS ; TRANSGENIC MICE ; GAMMA-SECRETASE ; IN-VIVO ; BETA ; DROSOPHILA ; BT-11 ; RAT
收录类别	SCI
语种	英语
WOS记录号	WOS:000345250400015
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/239]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Hou, YJ,Wang, Y,Zhao, J,et al. Smart Soup, a Traditional Chinese Medicine Formula, Ameliorates Amyloid Pathology and Related Cognitive Deficits[J]. PLOS ONE,2014,9(11):e111215-e111215.
APA	Hou, YJ.,Wang, Y.,Zhao, J.,Li, XH.,Cui, J.,...&Pei, G.(2014).Smart Soup, a Traditional Chinese Medicine Formula, Ameliorates Amyloid Pathology and Related Cognitive Deficits.PLOS ONE,9(11),e111215-e111215.
MLA	Hou, YJ,et al."Smart Soup, a Traditional Chinese Medicine Formula, Ameliorates Amyloid Pathology and Related Cognitive Deficits".PLOS ONE 9.11(2014):e111215-e111215.