The minimalist architectures of viroporins and their therapeutic implications

	The minimalist architectures of viroporins and their therapeutic implications
	OuYang, B; Chou, JJ
刊名	BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
	2014
卷号	1838 期号:4 页码:1058-1067
关键词	Viroporin Structure M2 P7 Influenza Hepatitis C
通讯作者	Chou, JJ (reprint author), Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China.,james_chou@hms.harvard.edu
英文摘要	Many viral genomes encode small, integral membrane proteins that form homo-oligomeric channels in membrane, and they transport protons, cations, and other molecules across the membrane barrier to aid various steps of viral entry and maturation. These viral proteins, collectively named viroporins, are crucial for viral pathogenicity. In the past five years, structures obtained by nuclear magnetic resonance (NMR), X-ray crystallography, and electron microscopy (EM) showed that viroporins often adopt minimalist architectures to achieve their functions. A number of small molecules have been identified to interfere with their channel activities and thereby inhibit viral infection, making viroporins potential drug targets for therapeutic intervention. The known architectures and inhibition mechanisms of viroporins differ significantly from each other, but some common principles are shared between them. This review article summarizes the recent developments in the structural investigation of viroporins and their inhibition by antiviral compounds. This article is part of a Special Issue entitled: Viral Membrane Proteins Channels for Cellular Networking. (C) 2013 Elsevier B.V. All rights reserved.
学科主题	Biochemistry & Molecular Biology; Biophysics
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]	HEPATITIS-C-VIRUS ; INFLUENZA-A VIRUS ; ION-CHANNEL ACTIVITY ; M2 PROTON CHANNELS ; INTEGRAL MEMBRANE-PROTEIN ; POLIOVIRUS 2B PROTEIN ; B VIRUS ; INFECTIOUS VIRUS ; BM2 PROTEIN ; P7 PROTEIN
收录类别	SCI
语种	英语
WOS记录号	WOS:000333507700002
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/179]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	OuYang, B,Chou, JJ. The minimalist architectures of viroporins and their therapeutic implications[J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES,2014,1838(4):1058-1067.
APA	OuYang, B,&Chou, JJ.(2014).The minimalist architectures of viroporins and their therapeutic implications.BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES,1838(4),1058-1067.
MLA	OuYang, B,et al."The minimalist architectures of viroporins and their therapeutic implications".BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1838.4(2014):1058-1067.