New insights into the regulation of Axin function in canonical Wnt signaling pathway

	New insights into the regulation of Axin function in canonical Wnt signaling pathway
	Song, XM; Wang, S; Li, L
刊名	PROTEIN & CELL
	2014
卷号	5 期号:3 页码:186-193
关键词	Wnt signaling Axin post-transcriptional modification polymerization auto-inhibition
通讯作者	Li, L (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Mol Biol, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China.,lli@sibs.ac.cn
英文摘要	The Wnt signaling pathway plays crucial roles during embryonic development, whose aberration is implicated in a variety of human cancers. Axin, a key component of canonical Wnt pathway, plays dual roles in modulating Wnt signaling: on one hand, Axin scaffolds the "beta-catenin destruction complex" to promote beta-catenin degradation and therefore inhibits the Wnt signal transduction; on the other hand, Axin interacts with LRP5/6 and facilitates the recruitment of GSK3 to the plasma membrane to promote LRP5/6 phosphorylation and Wnt signaling. The differential assemblies of Axin with these two distinct complexes have to be tightly controlled for appropriate transduction of the "on" or "off" Wnt signal. So far, there are multiple mechanisms revealed in the regulation of Axin activity, such as post-transcriptional modulation, homo/hetero-polymerization and auto-inhibition. These mechanisms may work cooperatively to modulate the function of Axin, thereby playing an important role in controlling the canonical Wnt signaling. In this review, we will focus on the recent progresses regarding the regulation of Axin function in canonical Wnt signaling.
学科主题	Cell Biology
类目[WOS]	Cell Biology
关键词[WOS]	ADENOMATOUS POLYPOSIS-COLI ; BETA-CATENIN DEGRADATION ; DIX DOMAIN ; NEGATIVE REGULATOR ; DISHEVELLED PROTEIN ; STABILIZES AXIN ; LUNG-CANCER ; C-TERMINUS ; E3 LIGASE ; PHOSPHORYLATION
收录类别	SCI
语种	英语
WOS记录号	WOS:000333805700004
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/160]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Song, XM,Wang, S,Li, L. New insights into the regulation of Axin function in canonical Wnt signaling pathway[J]. PROTEIN & CELL,2014,5(3):186-193.
APA	Song, XM,Wang, S,&Li, L.(2014).New insights into the regulation of Axin function in canonical Wnt signaling pathway.PROTEIN & CELL,5(3),186-193.
MLA	Song, XM,et al."New insights into the regulation of Axin function in canonical Wnt signaling pathway".PROTEIN & CELL 5.3(2014):186-193.