Experimental evidence for alleviating nociceptive hypersensitivity by single application of capsaicin

	Experimental evidence for alleviating nociceptive hypersensitivity by single application of capsaicin
	Ma, XL; Zhang, FX; Dong, F; Bao, L; Zhang, X
刊名	MOLECULAR PAIN
	2015
卷号	11 期号:1 页码:22-22
通讯作者	Zhang, X (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,xu.zhang@ion.ac.cn
英文摘要	The single application of high-concentration of capsaicin has been used as an analgesic therapy of persistent pain. However, its effectiveness and underlying mechanisms remain to be further evaluated with experimental approaches. The present study provided evidence showing that the single application of capsaicin dose-dependently alleviated nociceptive hypersensitivity, and reduced the action potential firing in small-diameter neurons of the dorsal root ganglia (DRG) in rats and mice. Pre-treatment with capsaicin reduced formalin-induced acute nocifensive behavior after a brief hyperalgesia in rats and mice. The inhibitory effects of capsaicin were calcium-dependent, and mediated by the capsaicin receptor (transient receptor potential vanilloid type-1). We further found that capsaicin exerted inhibitory effects on the persistent nociceptive hypersensitivity induced by peripheral inflammation and nerve injury. Thus, these results support the long-lasting and inhibitory effects of topical capsaicin on persistent pain, and the clinic use of capsaicin as a pain therapy.
学科主题	Neurosciences & Neurology
类目[WOS]	Neurosciences
关键词[WOS]	DORSAL-ROOT GANGLION ; PERIPHERAL NEUROPATHIC PAIN ; PRIMARY AFFERENT NEURONS ; EPIDERMAL NERVE-FIBERS ; GATED SODIUM CURRENTS ; TOPICAL CAPSAICIN ; VANILLOID RECEPTOR ; 8-PERCENT PATCH ; SENSORY NEURONS ; INFLAMMATORY PAIN
收录类别	SCI
语种	英语
WOS记录号	WOS:000353947400001
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/105]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Ma, XL,Zhang, FX,Dong, F,et al. Experimental evidence for alleviating nociceptive hypersensitivity by single application of capsaicin[J]. MOLECULAR PAIN,2015,11(1):22-22.
APA	Ma, XL,Zhang, FX,Dong, F,Bao, L,&Zhang, X.(2015).Experimental evidence for alleviating nociceptive hypersensitivity by single application of capsaicin.MOLECULAR PAIN,11(1),22-22.
MLA	Ma, XL,et al."Experimental evidence for alleviating nociceptive hypersensitivity by single application of capsaicin".MOLECULAR PAIN 11.1(2015):22-22.