Defective Repair of Uracil Causes Telomere Defects in Mouse Hematopoietic Cells

	Defective Repair of Uracil Causes Telomere Defects in Mouse Hematopoietic Cells
	Vallabhaneni, H; Zhou, F; Maul, RW; Sarkar, J; Yin, JH; Lei, M; Harrington, L; Gearhart, PJ; Liu, Y
刊名	JOURNAL OF BIOLOGICAL CHEMISTRY
	2015
卷号	290 期号:9 页码:5502-5511
通讯作者	Gearhart, PJ (reprint author), NIA, Lab Mol Biol & Immunol, NIH, Baltimore, MD 21224 USA.,gearhartp@mail.nih.gov ; liuyie@mail.nih.gov
英文摘要	Calcium transients in the cell nucleus evoked by synaptic activity in hippocampal neurons function as a signaling end point in synapse-to-nucleus communication. As an important regulator of neuronal gene expression, nuclear calcium is involved in the conversion of synaptic stimuli into functional and structural changes of neurons. Here we identify two synaptic organizers, Lrrtm1 and Lrrtm2, as targets of nuclear calcium signaling. Expression of both Lrrtm1 and Lrrtm2 increased in a synaptic NMDA receptor- and nuclear calcium-dependent manner in hippocampal neurons within 2-4 h after the induction of action potential bursting. Induction of Lrrtm1 and Lrrtm2 occurred independently of the need for new protein synthesis and required calcium/calmodulin-dependent protein kinases and the nuclear calcium signaling target CREB-binding protein. Analysis of reporter gene constructs revealed a functional cAMP response element in the proximal promoter of Lrrtm2, indicating that at least Lrrtm2 is regulated by the classical nuclear Ca2+ /calmodulin-dependent protein kinase IV-CREB/CREB-binding protein pathway. These results suggest that one mechanism by which nuclear calcium signaling controls neuronal network function is by regulating the expression of Lrrtm1 and Lrrtm2.
学科主题	Biochemistry & Molecular Biology
类目[WOS]	Biochemistry & Molecular Biology
关键词[WOS]	SISTER-CHROMATID EXCHANGE ; SINGLE-STRANDED-DNA ; ABERRANT HOMOLOGOUS RECOMBINATION ; BASE EXCISION-REPAIR ; TETRAHYMENA TELOMERASE ; REVERSE-TRANSCRIPTASE ; LENGTH REGULATOR ; FRAGILE SITES ; POT1 PROTEINS ; STEM-CELLS
收录类别	SCI
语种	英语
WOS记录号	WOS:000350044200022
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/90]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Vallabhaneni, H,Zhou, F,Maul, RW,et al. Defective Repair of Uracil Causes Telomere Defects in Mouse Hematopoietic Cells[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2015,290(9):5502-5511.
APA	Vallabhaneni, H.,Zhou, F.,Maul, RW.,Sarkar, J.,Yin, JH.,...&Liu, Y.(2015).Defective Repair of Uracil Causes Telomere Defects in Mouse Hematopoietic Cells.JOURNAL OF BIOLOGICAL CHEMISTRY,290(9),5502-5511.
MLA	Vallabhaneni, H,et al."Defective Repair of Uracil Causes Telomere Defects in Mouse Hematopoietic Cells".JOURNAL OF BIOLOGICAL CHEMISTRY 290.9(2015):5502-5511.