Pyruvate kinase M2 at a glance

	Pyruvate kinase M2 at a glance
	Yang, WW; Lu, ZM
刊名	JOURNAL OF CELL SCIENCE
	2015
卷号	128 期号:9 页码:1655-1660
关键词	PKM2 Pyruvate kinase M2 Metabolism reprogramming Protein kinase Gene transcription
通讯作者	Yang, WW (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, Shanghai 200031, Peoples R China.,weiweiyang@sibcb.ac.cn ; zhiminlu@mdanderson.org
英文摘要	Reprogrammed metabolism is a key feature of cancer cells. The pyruvate kinase M2 (PKM2) isoform, which is commonly upregulated in many human cancers, has been recently shown to play a crucial role in metabolism reprogramming, gene transcription and cell cycle progression. In this Cell Science at a glance article and accompanying poster, we provide a brief overview of recent advances in understanding the mechanisms underlying the regulation of PKM2 expression, enzymatic activity, metabolic functions and subcellular location. We highlight the instrumental role of the non-metabolic functions of PKM2 in tumorigenesis and evaluate the potential to target PKM2 for cancer treatment.
学科主题	Cell Biology
类目[WOS]	Cell Biology
关键词[WOS]	TUMOR-GROWTH ; PROTEIN-KINASE ; NUCLEAR TRANSLOCATION ; GENE-TRANSCRIPTION ; CELL-PROLIFERATION ; CANCER METABOLISM ; PKM2 EXPRESSION ; BINDING PROTEIN ; ISOFORM M2 ; PROMOTES
收录类别	SCI
语种	英语
WOS记录号	WOS:000354873100001
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/88]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Yang, WW,Lu, ZM. Pyruvate kinase M2 at a glance[J]. JOURNAL OF CELL SCIENCE,2015,128(9):1655-1660.
APA	Yang, WW,&Lu, ZM.(2015).Pyruvate kinase M2 at a glance.JOURNAL OF CELL SCIENCE,128(9),1655-1660.
MLA	Yang, WW,et al."Pyruvate kinase M2 at a glance".JOURNAL OF CELL SCIENCE 128.9(2015):1655-1660.