Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal T(H)17 responses

	Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal T(H)17 responses
	Deng, ZH; Ma, SX; Zhou, H; Zang, AP; Fang, YY; Li, TT; Shi, HJ; Liu, M; Du, M; Taylor, PR
刊名	NATURE IMMUNOLOGY
	2015
卷号	16 期号:6 页码:642-642
通讯作者	Xiao, H (reprint author), Chinese Acad Sci, Vaccine Ctr, Inst Pasteur Shanghai, Key Lab Mol Virol & Immunol, Shanghai, Peoples R China.,huixiao@ips.ac.cn
英文摘要	Fungal infection stimulates the canonical C-type lectin receptor (CLR) signaling pathway via activation of the tyrosine kinase Syk. Here we identify a crucial role for the tyrosine phosphatase SHP-2 in mediating CLR-induced activation of Syk. Ablation of the gene encoding SHP-2 (Ptpn11; called 'Shp-2' here) in dendritic cells (DCs) and macrophages impaired Syk-mediated signaling and abrogated the expression of genes encoding pro-inflammatory molecules following fungal stimulation. Mechanistically, SHP-2 operated as a scaffold, facilitating the recruitment of Syk to the CLR dectin-1 or the adaptor FcR gamma, through its N-SH2 domain and a previously unrecognized carboxy-terminal immunoreceptor tyrosine-based activation motif (ITAM). We found that DC-derived SHP-2 was crucial for the induction of interleukin 1 beta (IL-1 beta), IL-6 and IL-23 and anti-fungal responses of the T(H)17 subset of helper T cells in controlling infection with Candida albicans. Together our data reveal a mechanism by which SHP-2 mediates the activation of Syk in response to fungal infection.
学科主题	Immunology
类目[WOS]	Immunology
关键词[WOS]	PATTERN-RECOGNITION RECEPTOR ; DENDRITIC CELLS ; FUNGAL-INFECTIONS ; CANDIDA-ALBICANS ; IMMUNE-RESPONSES ; INNATE IMMUNITY ; HOST-DEFENSE ; DECTIN-1 ; INDUCTION ; PATHWAY
收录类别	SCI
语种	英语
WOS记录号	WOS:000354751900017
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/74]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Deng, ZH,Ma, SX,Zhou, H,et al. Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal T(H)17 responses[J]. NATURE IMMUNOLOGY,2015,16(6):642-642.
APA	Deng, ZH.,Ma, SX.,Zhou, H.,Zang, AP.,Fang, YY.,...&Xiao, H.(2015).Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal T(H)17 responses.NATURE IMMUNOLOGY,16(6),642-642.
MLA	Deng, ZH,et al."Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal T(H)17 responses".NATURE IMMUNOLOGY 16.6(2015):642-642.