Sensing and responding to cytosolic viruses invasions: An orchestra of kaleidoscopic ubiquitinations

	Sensing and responding to cytosolic viruses invasions: An orchestra of kaleidoscopic ubiquitinations
	Liu, X; Wang, Q; Pan, YD; Wang, C
刊名	CYTOKINE & GROWTH FACTOR REVIEWS
	2015
卷号	26 期号:3 页码:379-387
关键词	Ubiquitin RIG-I STING Post-translational modification Innate immunity
通讯作者	Wang, C (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China.,cwang01@sibcb.ac.cn
英文摘要	Ubiquitin is a versatile molecular signature that modulates diverse cellular processes via proteasome-dependent and proteasome-independent mechanisms. The covalent and/or non-covalent binding of mono-ubiquitin and/or poly-ubiquitin chains to a target protein broadens the dynamic and functional spectra for signal integration. Different linkages of poly-ubiquitin chains determine specific physiological or pathological functions of target proteins. Accumulating evidences has revealed the essential roles of ubiquitination in orchestrating the host defenses against cytosolic RNA or DNA from viral infections. In this review, we summarize the current progress regarding the understanding of ubiquitin-mediated regulation of the RIG-I and STING antiviral signaling pathways and discuss certain critical issues that remain to be resolved in future studies. (C) 2015 Elsevier Ltd. All rights reserved.
学科主题	Biochemistry & Molecular Biology ; Cell Biology
类目[WOS]	Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]	INNATE IMMUNE-RESPONSE ; INTERFERON REGULATORY FACTOR-3 ; PATTERN-RECOGNITION RECEPTORS ; CELLULAR ANTIVIRAL RESPONSE ; RIG-I ; INTRACELLULAR DNA ; RNA VIRUSES ; ENDOPLASMIC-RETICULUM ; PATHOGEN RECOGNITION ; POLYUBIQUITIN CHAINS
收录类别	SCI
语种	英语
WOS记录号	WOS:000356209500009
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/30]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Liu, X,Wang, Q,Pan, YD,et al. Sensing and responding to cytosolic viruses invasions: An orchestra of kaleidoscopic ubiquitinations[J]. CYTOKINE & GROWTH FACTOR REVIEWS,2015,26(3):379-387.
APA	Liu, X,Wang, Q,Pan, YD,&Wang, C.(2015).Sensing and responding to cytosolic viruses invasions: An orchestra of kaleidoscopic ubiquitinations.CYTOKINE & GROWTH FACTOR REVIEWS,26(3),379-387.
MLA	Liu, X,et al."Sensing and responding to cytosolic viruses invasions: An orchestra of kaleidoscopic ubiquitinations".CYTOKINE & GROWTH FACTOR REVIEWS 26.3(2015):379-387.