JMJD3 promotes chondrocyte proliferation and hypertrophy during endochondral bone formation in mice

	JMJD3 promotes chondrocyte proliferation and hypertrophy during endochondral bone formation in mice
	Zhang, F; Xu, LY; Xu, LX; Xu, Q; Li, DS; Yang, YZ; Karsenty, G; Chen, CD
刊名	JOURNAL OF MOLECULAR CELL BIOLOGY
	2015
卷号	7 期号:1 页码:23-34
关键词	JMJD3 RUNX2 chondrocyte endochondral bone formation
通讯作者	Chen, CD (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol,Shanghai Key Lab Mol Andro, Shanghai 200031, Peoples R China.,cdchen@sibcb.ac.cn
英文摘要	JMJD3 (KDM6B) is an H3K27me3 demethylase and counteracts polycomb-mediated transcription repression. However, the function of JMJD3 in vivo is not well understood. Here we show that JMJD3 is highly expressed in cells of the chondrocyte lineage, especially in prehypertrophic and hypertrophic chondrocytes, during endochondral ossification. Homozygous deletion of Jmjd3 results in severely decreased proliferation and delayed hypertrophy of chondrocytes, and thereby marked retardation of endochondral ossification in mice. Genetically, JMJD3 associates with RUNX2 to promote proliferation and hypertrophy of chondrocytes. Biochemically, JMJD3 associates with and enhances RUNX2 activity by derepression of Runx2 and Ihh transcription through its H3K27me3 demethylase activity. These results demonstrate that JMJD3 is a key epigenetic regulator in the process of cartilage maturation during endochondral bone formation.
学科主题	Cell Biology
类目[WOS]	Cell Biology
关键词[WOS]	EMBRYONIC STEM-CELLS ; HISTONE LYSINE METHYLATION ; DEMETHYLASE JMJD3 ; H3K27 DEMETHYLASE ; GENE-EXPRESSION ; METHYLTRANSFERASE ACTIVITY ; DEVELOPMENTAL REGULATORS ; CBFA1-DEFICIENT MICE ; INDIAN-HEDGEHOG ; GROWTH PLATES
收录类别	SCI
语种	英语
WOS记录号	WOS:000350228600004
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/8]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Zhang, F,Xu, LY,Xu, LX,et al. JMJD3 promotes chondrocyte proliferation and hypertrophy during endochondral bone formation in mice[J]. JOURNAL OF MOLECULAR CELL BIOLOGY,2015,7(1):23-34.
APA	Zhang, F.,Xu, LY.,Xu, LX.,Xu, Q.,Li, DS.,...&Chen, CD.(2015).JMJD3 promotes chondrocyte proliferation and hypertrophy during endochondral bone formation in mice.JOURNAL OF MOLECULAR CELL BIOLOGY,7(1),23-34.
MLA	Zhang, F,et al."JMJD3 promotes chondrocyte proliferation and hypertrophy during endochondral bone formation in mice".JOURNAL OF MOLECULAR CELL BIOLOGY 7.1(2015):23-34.