4,5-Cis Unsaturated alpha-GalCer Analogues Distinctly Lead to CD1d-Mediated Th1-Biased NKT Cell Responses

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	4,5-Cis Unsaturated alpha-GalCer Analogues Distinctly Lead to CD1d-Mediated Th1-Biased NKT Cell Responses
	Cui, Yanli; Li, Zhiyuan; Cheng, Zhaodong; Xia, Chengfeng; Zhang, Yongmin
刊名	CHEMICAL RESEARCH IN TOXICOLOGY
	2015-06-01
卷号	28 期号:6 页码:1209-1215
通讯作者	Cui,YL (reprint author),Zhejiang Univ,Dept Chem,Hangzhou 310027,Peoples R China. ; hnzzcyl@hotmail.com ; xiachengfeng@mail.kib.ac.cn ; yongmin.zhang@ipcm.upmc.fr
英文摘要	The total synthesis of 4,5-cis unsaturated alpha-GalCer analogues was achieved, and their immune-response altering activity was assessed in vitro as well as in vivo in mice. Using glycosyl iodide as a glycosyl donor, construction of the sphingosine unit was shortened by four steps and single alpha-stereoselectivity was achieved in good yield (67%). With regard to the therapeutic use of alpha-GalCer, the novel analogues (1b and 1c) distinctly induced a Th1-biased cytokine response, avoiding induction of a contradictory response and overstimulation.
学科主题	Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology
类目[WOS]	Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Toxicology
研究领域[WOS]	Pharmacology & Pharmacy ; Chemistry ; Toxicology
关键词[WOS]	KILLER T-CELLS ; GALACTOSYLCERAMIDE KRN7000 ; HUMAN CD1D ; INKT CELL ; ANTITUMOR ACTIVITIES ; RECOGNITION ; GLYCOLIPIDS ; ACTIVATION ; ANERGY
收录类别	SCI
语种	英语
WOS记录号	WOS:000356467300013
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/21352]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Cui, Yanli,Li, Zhiyuan,Cheng, Zhaodong,et al. 4,5-Cis Unsaturated alpha-GalCer Analogues Distinctly Lead to CD1d-Mediated Th1-Biased NKT Cell Responses[J]. CHEMICAL RESEARCH IN TOXICOLOGY,2015,28(6):1209-1215.
APA	Cui, Yanli,Li, Zhiyuan,Cheng, Zhaodong,Xia, Chengfeng,&Zhang, Yongmin.(2015).4,5-Cis Unsaturated alpha-GalCer Analogues Distinctly Lead to CD1d-Mediated Th1-Biased NKT Cell Responses.CHEMICAL RESEARCH IN TOXICOLOGY,28(6),1209-1215.
MLA	Cui, Yanli,et al."4,5-Cis Unsaturated alpha-GalCer Analogues Distinctly Lead to CD1d-Mediated Th1-Biased NKT Cell Responses".CHEMICAL RESEARCH IN TOXICOLOGY 28.6(2015):1209-1215.