Glutathione S-transferase (GST) gene expression profiles in two marine bivalves exposed to BDE-47 and their potential molecular mechanisms

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 中科院海岸带环境过程与生态修复重点实验室

	Glutathione S-transferase (GST) gene expression profiles in two marine bivalves exposed to BDE-47 and their potential molecular mechanisms
	Li Fei; Wu Huifeng; Zhao Jianmin; Zhao Jianmin; Wang Qing
刊名	CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
	2015-05
卷号	33 期号:3 页码:705-713
关键词	glutathione S-transferase (GST) Venerupis philippinarum Mytilus galloprovincialis 2 molecular docking biomarker 2 ' 4 4 '-tetrabromodiphenyl ether (BDE-47)
ISSN号	0254-4059
通讯作者	Wu, HF (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China. hfwu@yic.ac.cn
产权排序	[Li Fei; Wu Huifeng; Wang Qing; Zhao Jianmin] Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China; [Li Xuehua] Dalian Univ Technol, Sch Environm Sci & Technol, Key Lab Ind Ecol & Environm Engn MOE, Dalian 116024, Peoples R China
中文摘要	Glutathione S-transferases (GSTs) are phase II enzymes that facilitate the detoxification of xenobiotics and play important roles in antioxidant defense. We investigated the expression patterns of seven Venerupis philippinarum GSTs (VpGSTs) and four Mytilus galloprovincialis GSTs (MgGSTs) following exposure to BDE-47. Differential expressions of the seven VpGSTs and four Mg GSTs transcripts were observed, with differences between the hepatopancreas and gills. Among these GSTs, the sigma classes (VpGSTS1, VpGSTS2, VpGSTS3, MgGST1, and MgGST3) were highly expressed in response to BDE-47 exposure, demonstrating their potential as molecular biomarkers for environmental biomonitoring studies. We obtained the three-dimensional crystal structures of VpGSTs and MgGSTs by homologous modeling. A model to elucidate the binding interactions between the ligands and receptors was defined by molecular docking. Hydrophobic and pi were the most often observed interactions between BDE-47 and the GSTs.
学科主题	Limnology; Oceanography
研究领域[WOS]	National Natural Science Foundation of China [21107136] ; International Foundation for Science [F/5230-1]
关键词[WOS]	POLYBROMINATED DIPHENYL ETHERS ; OMEGA-CLASS ; VENERUPIS-PHILIPPINARUM ; NORTH CHINA ; FETAL BLOOD ; BOHAI BAY ; IN-VITRO ; MU-CLASS ; CLONING ; HYDROCARBONS
收录类别	SCI
语种	英语
WOS记录号	WOS:000353891400016
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/8624]
专题	烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
推荐引用方式 GB/T 7714	Li Fei,Wu Huifeng,Zhao Jianmin,et al. Glutathione S-transferase (GST) gene expression profiles in two marine bivalves exposed to BDE-47 and their potential molecular mechanisms[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2015,33(3):705-713.
APA	Li Fei,Wu Huifeng,Zhao Jianmin,Zhao Jianmin,&Wang Qing.(2015).Glutathione S-transferase (GST) gene expression profiles in two marine bivalves exposed to BDE-47 and their potential molecular mechanisms.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,33(3),705-713.
MLA	Li Fei,et al."Glutathione S-transferase (GST) gene expression profiles in two marine bivalves exposed to BDE-47 and their potential molecular mechanisms".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 33.3(2015):705-713.